A method of rapid quantification of patient-specific organ doses for CT using deep-learning-based multi-organ segmentation and GPU-accelerated Monte Carlo dose computing

Medical Physics
Zhao PengX George Xu

Abstract

One technical barrier to patient-specific computed tomography (CT) dosimetry has been the lack of computational tools for the automatic patient-specific multi-organ segmentation of CT images and rapid organ dose quantification. When previous CT images are available for the same body region of the patient, the ability to obtain patient-specific organ doses for CT - in a similar manner as radiation therapy treatment planning - will open the door to personalized and prospective CT scan protocols. This study aims to demonstrate the feasibility of combining deep-learning algorithms for automatic segmentation of multiple radiosensitive organs from CT images with the GPU-based Monte Carlo rapid organ dose calculation. A deep convolutional neural network (CNN) based on the U-Net for organ segmentation is developed and trained to automatically delineate multiple radiosensitive organs from CT images. Two databases are used: The lung CT segmentation challenge 2017 (LCTSC) dataset that contains 60 thoracic CT scan patients, each consisting of five segmented organs, and the Pancreas-CT (PCT) dataset, which contains 43 abdominal CT scan patients each consisting of eight segmented organs. A fivefold cross-validation method is performed on bot...Continue Reading

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Citations

Sep 3, 2020·European Journal of Nuclear Medicine and Molecular Imaging·Azadeh AkhavanallafHabib Zaidi
Sep 16, 2020·Investigative Radiology·John Damilakis
Dec 6, 2020·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Jiaxing TanYingli Tian
Nov 17, 2020·Medical Image Analysis·Renzhen WangDeyu Meng
Feb 16, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·David Fernández BosmanMercè Ginjaume
Mar 12, 2021·Computerized Medical Imaging and Graphics : the Official Journal of the Computerized Medical Imaging Society·Dongdong GuZhong Xue
Mar 26, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Hossein ArabiHabib Zaidi
May 17, 2021·Physica Medica : PM : an International Journal Devoted to the Applications of Physics to Medicine and Biology : Official Journal of the Italian Association of Biomedical Physics (AIFB)·Yabo FuXiaofeng Yang
Jun 19, 2021·Technology in Cancer Research & Treatment·Danju HuangWenhui Li

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