1. A simple method of stimulating different segments of the autonomic outflow from the spinal column in the pithed cat and rat is described.2. Using a movable Teflon-shielded electrode inserted into the vertebral canal and an indifferent electrode under the skin, reproducible responses were obtained from the adrenals, the bladder, the blood vessels, the colon, the heart and the vas deferens. The level and number of segments stimulated was altered by varying the depth of insertion of the Teflon tube and the length of central steel electrode protruding from it.3. The degree of localization of the stimulus seemed satisfactory since it was possible by stimulating the sacral parasympathetic outflow to the bladder and colon or the lumbar sympathetic outflow to the vas deferens, to elicit responses from these organs with little effect on the cardiovascular system. Stimulation at higher levels of the thoracic sympathetic outflow permitted discrimination between the pressor and cardio-accelerator responses.4. Hexamethonium (1 mg/kg) inhibited all the responses, but the colonic response, which occurred only after a latent period, was especially sensitive to ganglion blockade. Atropine (1 mg/kg) inhibited the bladder response by 50% but o...Continue Reading
A method of stimulating the complete sympathetic outflow from the spinal cord to blood vessels in the pithed rat
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Alpha-adrenoceptor activity of arylalkylimidazoles is improved by alpha-methylation and impaired by alpha-hydroxylation.
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Calcium entry blockers inhibit vasoconstrictor responses to sympathetic nerve stimulation mediated by alpha 1-adrenoceptors.
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Predominant role of the dopamine D3 receptor subtype for mediating the quinpirole-induced inhibition of the vasopressor sympathetic outflow in pithed rats
Capsaicin-sensitive nonadrenergic and noncholinergic depressor response to spinal cord stimulation in the pithed rat
Mezilamine, a new dopamine antagonist, blocks presynaptic but stimulates postsynaptic alpha-adrenoceptors
Changes of adrenoceptor-mediated responses in the pithed rat during propylthiouracil-induced hypothyroidism
Sgd 101/75 is distinguished from other selective alpha 1-adrenoceptor agonists by the inhibition of its pressor responses by calcium entry blockade and vasodilatation in pithed rats and cats
Cardiovascular action of detomidine, a sedative and analgesic imidazole derivative with alpha-agonistic properties
Comparison of the effects of detomidine and xylazine on some alpha 2-adrenoceptor-mediated responses in the central and peripheral nervous systems.
Chronic clonidine treatment produces desensitisation of post- but not presynaptic alpha 2-adrenoceptors
Comparison of the purinergic contribution to sympathetic vascular responses in SHR and WKY rats in vitro and in vivo
Modification of alpha-adrenoceptor-mediated pressor responses by NG-nitro-L-arginine methyl ester and vasopressin in endotoxin-treated pithed rats
Pressor responses to the alpha 1-adrenoceptor agonist cirazoline: effects of captopril, phenoxybenzamine and nifedipine
The cardiovascular actions of the volatile oil of the black seed (Nigella sativa) in rats: elucidation of the mechanism of action
Prenatal nicotine exposure impairs beta-adrenergic function: persistent chronotropic subsensitivity despite recovery from deficits in receptor binding
Differential effects of rANF and chronic guanabenz to presynaptic and postsynaptic alpha 2-adrenoceptor-mediated cardiovascular response in pithed rats
The 5-HT1-like receptors mediating inhibition of sympathetic vasopressor outflow in the pithed rat: operational correlation with the 5-HT1A, 5-HT1B and 5-HT1D subtypes
Characterization of mechanisms involved in presynaptic inhibition of sympathetic pressor effects induced by some 5-HT1 receptor antagonists
Cardiac electrophysiology is the study of electrical activities of the heart and includes the assessment, diagnosis, and treatment of cardiac events. Find the latest research on cardiac electrophysiology here.