A method to assess the quality of studies that examine the toxicity of engineered nanomaterials

International Journal of Toxicology
Jeffrey W Card, Bernadene A Magnuson

Abstract

As reports on the safety of various nanomaterials have yielded conflicting results, assessment of the reliability of each study is required to objectively interpret overall safety of the nanomaterial. A 2-step method to assess the quality of nanotoxicity studies is described. The first step uses a publicly available tool to rank the reliability of the study based on adequacy of design and documentation of methods, materials, and results, providing a "study score." The second step determines the completeness of physicochemical characterization of the nanomaterial/nanomaterials assessed within the study, providing a "nanomaterial score." This approach is encouraged to promote the notion that for studies conducted with nanomaterials, the combination of a reliable study and sufficient nanomaterial characterization is of significantly greater value than either of these alone. It is anticipated that the use and evolution of this approach will assist with the design and interpretation of studies assessing nanomaterial toxicity.

References

Feb 1, 1997·Regulatory Toxicology and Pharmacology : RTP·H J KlimischU Tillmann
Nov 6, 2003·Toxicological Sciences : an Official Journal of the Society of Toxicology·Edilberto BermudezJeffrey I Everitt
Dec 29, 2004·Life Sciences·Jinsong ZhangLide Zhang
Sep 24, 2005·Toxicological Sciences : an Official Journal of the Society of Toxicology·Alison ElderGünter Oberdörster
Oct 8, 2005·Particle and Fibre Toxicology·Günter OberdörsterUNKNOWN ILSI Research Foundation/Risk Science Institute Nanomaterial Toxicity Screening Working Group
Nov 18, 2005·Toxicology Letters·Zhen ChenLijun Wan
Jan 13, 2006·Toxicological Sciences : an Official Journal of the Society of Toxicology·Kevin W PowersStephen M Roberts
Feb 4, 2006·Science·Andre NelNing Li
Aug 16, 2006·Particle and Fibre Toxicology·Paul J A BormEva Oberdorster
Apr 25, 2007·Journal of Nanoscience and Nanotechnology·J Michael Davis
May 19, 2007·Inhalation Toxicology·David B WarheitJürgen Lademann
Jul 3, 2007·Toxicological Sciences : an Official Journal of the Society of Toxicology·Stephan T Stern, Scott E McNeil
Nov 17, 2007·Environmental Health Perspectives·John M BalbusBrian A Wong
Feb 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·David B Warheit
Nov 27, 2008·Toxicological Sciences : an Official Journal of the Society of Toxicology·Jae Hyuck SungIl Je Yu
May 27, 2009·Toxicological Sciences : an Official Journal of the Society of Toxicology·Nigel J Walker, John R Bucher
May 30, 2009·Toxicology Letters·Klaus SchneiderSebastian Hoffmann
May 30, 2009·Environmental Health Perspectives·Janne K FolkmannPeter Møller
Sep 12, 2009·Critical Reviews in Toxicology·Amy K Madl, Kent E Pinkerton
Oct 6, 2009·Journal of Food Science·Jeffrey W Card, Bernadene A Magnuson
Oct 20, 2009·Toxicology Letters·Tomas S JonaitisBernadene Magnuson
Feb 1, 2009·Journal of Nanoparticle Research : an Interdisciplinary Forum for Nanoscale Science and Technology·Alexis D OstrowskiBarbara Herr Harthorn

❮ Previous
Next ❯

Citations

Jun 11, 2015·Environmental Toxicology and Chemistry·Elena SemenzinAntonio Marcomini
Nov 26, 2015·Toxicology and Applied Pharmacology·Hedwig M BraakhuisFlemming R Cassee
Mar 16, 2012·Journal of Food Science·Bernadene A MagnusonJeffrey W Card
Mar 3, 2015·Environmental Toxicology and Chemistry·Amy BeasleyRyan R Otter
Jan 17, 2012·Food and Chemical Toxicology : an International Journal Published for the British Industrial Biological Research Association·Andrew CockburnTanja Wildemann
Oct 20, 2017·International Journal of Environmental Research and Public Health·Janeck J Scott-FordsmandKerstin Hund-Rinke
Sep 17, 2011·American Journal of Physiology. Gastrointestinal and Liver Physiology·Jeffrey W Card, Bernadene A Magnuson
Nov 17, 2010·Critical Reviews in Toxicology·Jeffrey W CardBernadene A Magnuson
Mar 6, 2019·Nanomaterials·James D EdeJo Anne Shatkin
Sep 11, 2020·Nanotoxicology·Natasha StoudmannClaudia Som
Jul 4, 2020·Environmental Toxicology and Chemistry·Joseph S MeyerChristian E Schlekat

❮ Previous
Next ❯

Software Mentioned

ToxRTool

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

Related Papers

Food Additives & Contaminants. Part A, Chemistry, Analysis, Control, Exposure & Risk Assessment
Qasim ChaudhryRichard Watkins
© 2021 Meta ULC. All rights reserved