A methodological approach for assessing the uptake of core outcome sets using ClinicalTrials.gov: findings from a review of randomised controlled trials of rheumatoid arthritis

BMJ : British Medical Journal
Jamie J KirkhamPaula R Williamson

Abstract

Objective To assess the uptake of the rheumatoid arthritis core outcome set using a new assessment method of calculating uptake from data in clinical trial registry entries.Design Review of randomised trials.Setting ClinicalTrials.gov.Subjects 273 randomised trials of drug interventions for the treatment of rheumatoid arthritis and registered in ClinicalTrials.gov between 2002 and 2016. Full publications were identified for completed studies from information in the trial registry or from an internet search using Google and the citation database Web of Science.Main outcome measure The percentage of trials reporting or planning to measure the rheumatoid arthritis core outcome set calculated from the information presented in the trial registry and compared with the percentage reporting the rheumatoid arthritis core outcome set in the resulting trial publications.Results The full rheumatoid arthritis core outcome set was reported in 81% (116/143) of trials identified on the registry as completed (or terminated) for which results were found in either the published literature or the registry. For trials identified on the registry as completed (or terminated), using information only available in the registry gives an estimate for upta...Continue Reading

Citations

Oct 28, 2017·Journal of Evaluation in Clinical Practice·Amy PriceAmanda Burls
Aug 3, 2017·The Journal of Rheumatology·Sean R TunisPeter Tugwell
Feb 14, 2018·Gut·Kapil SahnanUNKNOWN ENiGMA collaborators
Feb 3, 2019·The Journal of Rheumatology·Dorcas E BeatonPeter Tugwell
Feb 28, 2020·BMC Medical Research Methodology·Michela MeregagliaGiovanni Fattore
Mar 14, 2020·Critical Care Medicine·Louise RoseUNKNOWN Development of Core Outcome Sets for Effectiveness Trials of Interventions to Prevent and/or Treat Delirium (Del-COrS) Group
Feb 18, 2020·The Journal of Rheumatology·Danyal Z KhanMark R N Kotter
Mar 3, 2020·BMJ Open·Ben Arthur MarsonUNKNOWN CORE-Kids Group
Nov 17, 2019·Archives of Disease in Childhood. Fetal and Neonatal Edition·James William Harrison WebbeChris Gale
Jul 2, 2020·British Journal of Health Psychology·Karen Matvienko-SikarMolly Byrne
Jul 31, 2020·Expert Opinion on Drug Metabolism & Toxicology·Diego Pilati, Kenneth A Howard
Aug 22, 2018·JAMA Ophthalmology·Ian J SaldanhaEsen K Akpek
Mar 25, 2020·Critical Care Medicine·Louise RoseUNKNOWN Development of Core Outcome Sets for Effectiveness Trials of Interventions to Prevent and/or Treat Delirium (Del-COrS) Group
Mar 14, 2018·Proceedings of the National Academy of Sciences of the United States of America·Kay Dickersin, Evan Mayo-Wilson
Nov 22, 2020·Diabetes Care·Aoife M EganUNKNOWN INSPIRED research group
Mar 13, 2021·HRB Open Research·Karen Matvienko-SikarUNKNOWN MRC-NIHR TMRP Outcomes Working Group Core Outcome Set Theme
Mar 18, 2019·Journal of the American Academy of Dermatology·Cecilia A C PrinsenJochen Schmitt
May 15, 2021·PloS One·Matthew E SmithUNKNOWN INTEGRATE (The UK ENT Trainee Research Network)
Dec 24, 2018·Ophthalmology·Ian J SaldanhaUNKNOWN Ophthalmology Outcomes Working Groups
Jun 2, 2021·The Australian & New Zealand Journal of Obstetrics & Gynaecology·Bobae V KimBen W Mol

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