A methodological survey of the analysis, reporting and interpretation of Absolute Risk ReductiOn in systematic revieWs (ARROW): a study protocol

Systematic Reviews
Pablo Alonso-CoelloGordon H Guyatt

Abstract

Clinicians, providers and guideline panels use absolute effects to weigh the advantages and downsides of treatment alternatives. Relative measures have the potential to mislead readers. However, little is known about the reporting of absolute measures in systematic reviews. The objectives of our study are to determine the proportion of systematic reviews that report absolute measures of effect for the most important outcomes, and ascertain how they are analyzed, reported and interpreted. We will conduct a methodological survey of systematic reviews published in 2010. We will conduct a 1:1 stratified random sampling of Cochrane vs. non-Cochrane systematic reviews. We will calculate the proportion of systematic reviews reporting at least one absolute estimate of effect for the most patient-important outcome for the comparison of interest. We will conduct multivariable logistic regression analyses with the reporting of an absolute estimate of effect as the dependent variable and pre-specified study characteristics as the independent variables. For systematic reviews reporting an absolute estimate of effect, we will document the methods used for the analysis, reporting and interpretation of the absolute estimate. Our methodological...Continue Reading

References

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Citations

Nov 13, 2015·Journal of Clinical Epidemiology·Pablo Alonso-CoelloGordon H Guyatt
May 24, 2015·The Spine Journal : Official Journal of the North American Spine Society·Nathan EvaniewGordon Guyatt
Sep 9, 2015·Implementation Science : IS·Susan E SlaughterErna Snelgrove-Clarke
Aug 25, 2016·Journal of Clinical Epidemiology·Arnav AgarwalPablo Alonso-Coello

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Software Mentioned

ARROW
Ovid
DistillerSR
GRADE
AMSTAR

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