PMID: 16639896Apr 28, 2006Paper

A methodology for deriving tissue residue benchmarks for aquatic biota: a case study for fish exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin and equivalents

Integrated Environmental Assessment and Management
Jeffery A SteevensAndrew V Pawlisz

Abstract

Tissue residue-based toxicity benchmarks (TRBs) have typically been developed using the results of individual studies selected from the literature. In the past, TRBs have been developed using a point estimate (e.g., LC50 value) reported in a study on a single species deemed to be most closely related to the receptor of interest. Despite attempts to maximize the protectiveness and relevance of TRBs, their relationship to specific receptors remains uncertain, and their general applicability for use in broader ecological risk assessment contexts is limited. This article proposes a novel framework that establishes benchmarks as distributions rather than single-point estimates. Benchmark distributions allow the user to select a tissue concentration that is associated with the protection of a specific percentage of organisms, rather than linked to a specific receptor. A methodology is proposed for searching, reviewing, and analyzing linked, tissue residue effect data to derive benchmark distributions. The approach is demonstrated for contaminants having a dioxin-like mechanism of toxic action and is based on residue effects data for 2,3,7,8-tetrachlorodibenzo-p-dioxin (2,3,7,8-TCDD) and equivalents in early life stage fish. The calcu...Continue Reading

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Citations

Aug 1, 2015·Environmental Toxicology and Chemistry·Edwin M FoekemaAlbertinka J Murk
Aug 18, 2009·Ecotoxicology and Environmental Safety·Henryka DabrowskaKrzysztof Radtke
Jul 21, 2007·Risk Analysis : an Official Publication of the Society for Risk Analysis·Richard R LesterIgor Linkov
Dec 25, 2010·Integrated Environmental Assessment and Management·L S McCartyA P van Wezel
Dec 25, 2010·Integrated Environmental Assessment and Management·Keith G SappingtonDoug J Spry
Sep 30, 2005·Aquatic Toxicology·Allen W Olmstead, Gerald A Leblanc
Mar 8, 2011·Environmental Toxicology and Chemistry·Erin R BennettKen G Drouillard
Dec 25, 2010·Integrated Environmental Assessment and Management·Anne E McElroyJeffery A Steevens

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