A Microbial Feed Additive Abates Intestinal Inflammation in Atlantic Salmon

Frontiers in Immunology
Ghana VasanthYoichiro Kitani

Abstract

The efficacy of a microbial feed additive (Bactocell(®)) in countering intestinal inflammation in Atlantic salmon was examined in this study. Fish were fed either the additive-coated feed (probiotic) or feed without it (control). After an initial 3-week feeding, an inflammatory condition was induced by anally intubating all the fish with oxazolone. The fish were offered the feeds for 3 more weeks. Distal intestine from the groups was obtained at 4 h, 24 h, and 3 weeks, after oxazolone treatment. Inflammatory responses were prominent in both groups at 24 h, documented by changes in intestinal micromorphology, expression of inflammation-related genes, and intestinal proteome. The control group was characterized by edema, widening of intestinal villi and lamina propria, infiltration of granulocytes and lymphocytes, and higher expression of genes related to inflammatory responses, mul1b, il1b, tnfa, ifng, compared to the probiotic group or other time points of the control group. Further, the protein expression in the probiotic group at 24 h after inducing inflammation revealed five differentially regulated proteins - Calr, Psma5, Trp1, Ctsb, and Naga. At 3 weeks after intubation, the inflammatory responses subsided in the probiotic...Continue Reading

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Citations

Nov 29, 2015·Developmental and Comparative Immunology·Viswanath KironOdd Elvebo
Dec 24, 2017·Probiotics and Antimicrobial Proteins·Natalia CatalánJaime Romero
Dec 29, 2020·Frontiers in Immunology·Viswanath KironViviane Verlhac Trichet
Jan 2, 2021·Developmental and Comparative Immunology·Ana Patrícia MateusDeborah M Power

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Datasets Mentioned

BETA
BT043501

Methods Mentioned

BETA
light microscopy
electrophoresis
PCR
Protein Assay

Software Mentioned

Protein Lynx Global Server Software
Mascot
Cell P
geNorm
GraphPad
GraphPad Prism
PDQuest Advanced

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