A microbiological study of Papillon-Lefévre syndrome in two patients

Journal of Clinical Pathology
K L RobertsonP S Bird

Abstract

To analyse the microflora of subgingival plaque from patients with Papillon-Lefévre syndrome (PLS), which is a very rare disease characterised by palmar-plantar hyperkeratosis with precocious periodontal destruction. Bacterial isolates were identified using a combination of commercial identification kits, traditional laboratory tests, and gas liquid chromatography. Some isolates were also subjected to partial 16S rDNA sequencing. Plaque samples were also assayed for the presence of Porphyromonas gingivalis, Prevotella intermedia, and Actinobacillus actinomycetemcomitans in a quantitative enzyme linked immunosorbent assay (ELISA) using monoclonal antibodies. The culture results showed that most isolates were capnophilic and facultatively anaerobic species-mainly Capnocytophaga spp and Streptococcus spp. The latter included S. constellatus, S. oralis, and S. sanguis. Other facultative bacteria belonged to the genera gemella, kingella, leuconostoc, and stomatococcus. The aerobic bacteria isolated were species of neisseria and bacillus. Anaerobic species included Prevotella intermedia, P. melaninogenica, and P. nigrescens, as well as Peptostreptococcus spp. ELISA detected P gingivalis in one patient in all sites sampled, whereas A....Continue Reading

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Citations

Oct 15, 2003·Clinical Microbiology Reviews·Timothy Andrews, Kathleen E Sullivan
Apr 29, 2005·Journal of Periodontology·Christopher J LuxPeter Eickholz
Dec 7, 2011·Journal of Periodontology·Jasim M AlbandarBruce J Paster
Jul 12, 2008·American Journal of Orthodontics and Dentofacial Orthopedics : Official Publication of the American Association of Orthodontists, Its Constituent Societies, and the American Board of Orthodontics·Naif A BindayelEmad Al-Farra
Dec 8, 2016·The FEBS Journal·Stephanie KettererThomas Reinheckel
Apr 18, 2014·Periodontology 2000·Ahmed Khocht, Jasim M Albandar
Oct 5, 2019·Journal of the Indian Society of Pedodontics and Preventive Dentistry·Shreya TyagiRuchika Kundra
Jul 17, 2021·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Heliya ZiaeiNima Rezaei

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