A microcholangiographic study of liver disease models in rats

Academic Radiology
S N LichtmanR L Clark

Abstract

Rats develop hepatobiliary injury due to small bowel bacterial overgrowth (SBBO) that, at specimen, resembles cholangiography sclerosing cholangitis. To better visualize the smaller bile ducts, we used microcholangiography to determine the spectrum of biliary lesions in this and five other models of liver disease. The models studied were as follows: (1) Surgically created jejunal, self-filling blind loops induce SBBO. (2) Intraperitoneal injection of a bacterial cell wall polymer, peptidoglycan-polysaccharide (PG-PS), causes granulomatous hepatitis. (3) Intraperitoneal injection of endotoxin (lipopolysaccharide) causes sinusoidal congestion and shock. (4) Bile duct ligation induces bile duct proliferation. (5) Alpha-naphthyl-isothiocyanate (ANIT) induces bile duct proliferation. (6) Carbon tetrachloride (CCl4) causes fibrosis and cirrhosis. Warmed barium sulfate, gelatin, and saline were injected in the extrahepatic bile duct. Liver slices (2 mm) underwent microradiographic techniques, and images were correlated with histology. Rats with SBBO had irregular and dilated extrahepatic bile ducts with thickened walls. Rats treated with endotoxin and CCl4 had normal microcholangiograms. Bile duct proliferation was identified followin...Continue Reading

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Citations

Jul 17, 2010·American Journal of Physiology. Gastrointestinal and Liver Physiology·J Anthony BrandonJ Scott Bryson
Nov 16, 2013·BioMed Research International·James H TabibianKeith D Lindor
Feb 25, 2014·Journal of Hepatology·Peter FickertUNKNOWN International PSC Study Group (IPSCSG)
Apr 19, 2011·Best Practice & Research. Clinical Gastroenterology·Melitta Penz-ÖsterreicherMichael Trauner
Nov 29, 2011·Best Practice & Research. Clinical Gastroenterology·Marion J PollheimerMichael Trauner
Aug 31, 2014·Clinical Reviews in Allergy & Immunology·Marion J Pollheimer, Peter Fickert
Aug 9, 2001·Best Practice & Research. Clinical Gastroenterology·J M Vierling
Oct 3, 2018·International Journal of Molecular Sciences·Debora Maria GiordanoMarco Marzioni
Jun 30, 2010·Nature Reviews. Gastroenterology & Hepatology·Scott L Friedman
Mar 30, 2018·Current Gastroenterology Reports·Amanda RicciutoAnne M Griffiths

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