PMID: 4003871Jan 1, 1985

A microcomputer based controller for neuromuscular block during surgery

Annals of Biomedical Engineering
G RitchieL C Sheppard


A microcomputer based control system has been developed to automatically induce and maintain neuromuscular block during surgery. The system repeatedly adjusts the infusion rate of a muscle relaxant, succinylcholine, based on the evoked, rectified, and integrated electromyogram (EMG). The system was tested in 12 patients for a 30-min infusion period with a setpoint of 80% depression of the evoked, rectified, and integrated thenar EMG. The mean time to reach the setpoint for 10 of the patients was 5.5 (+/- 1.87 SD) min and the mean time for 95% recovery after infusion was stopped was 5.4 (+/- 0.83 SD) min. Average overshoot was 9.9% of the baseline (+/- 3.1% SD), and the average time within +/- 10% of the setpoint was 22.1 min (+/- 7.26 SD). The total dose of succinylcholine for these 10 patients ranged from 1.21 to 3.77 mg/kg with a mean of 1.92 mg/kg. The other two patients were relatively insensitive to the drug and the controller was unable to bring the response to the setpoint due to a ceiling placed on infusion rate by the control algorithm.


Mar 1, 1994·Annals of Biomedical Engineering·K BehbehaniK Klein
Feb 1, 1989·Journal of Cardiothoracic Anesthesia·L C Sheppard
Aug 1, 1987·IEEE Transactions on Bio-medical Engineering·R R Jaklitsch, D R Westenskow
Aug 14, 2001·IEEE Transactions on Bio-medical Engineering·A GentiliniT W Schnider

Related Concepts

Computers, Digital
Surface Electromyography
Medical Device Design
Intraoperative Care
Personal Computers
Nerve Block
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