A Microfluidic Ion Pump for In Vivo Drug Delivery

Advanced Materials
Ilke UguzGeorge G Malliaras

Abstract

Implantable devices offer an alternative to systemic delivery of drugs for the treatment of neurological disorders. A microfluidic ion pump (µFIP), capable of delivering a drug without the solvent through electrophoresis, is developed. The device is characterized in vitro by delivering γ-amino butyric acid to a target solution, and demonstrates low-voltage operation, high drug-delivery capacity, and high ON/OFF ratio. It is also demonstrated that the device is suitable for cortical delivery in vivo by manipulating the local ion concentration in an animal model and altering neural behavior. These results show that µFIPs represent a significant step forward toward the development of implantable drug-delivery systems.

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Citations

Dec 22, 2017·Advanced Materials·Mary J DonahueGeorge G Malliaras
Jan 9, 2019·Advanced Materials·Magnus BerggrenIgor Zozoulenko
Mar 13, 2019·Advanced Materials·Erica ZeglioAnna Herland
Apr 4, 2019·Advanced Healthcare Materials·Kristina Fidanovski, Damia Mawad
Sep 14, 2019·Advanced Materials·Amy E RochfordDamiano G Barone
Jan 25, 2020·Advanced Healthcare Materials·Alain da Silva MoraisRui L Reis
Sep 1, 2018·Science Advances·Christopher M ProctorGeorge G Malliaras
Aug 15, 2018·International Journal of Molecular Sciences·Krishna FeronPaul C Dastoor
Aug 14, 2019·Nature Biotechnology·James A FrankPolina Anikeeva
Apr 2, 2020·Bioelectronic Medicine·Bettina HabeltIvan Minev
Apr 30, 2020·Scientific Reports·Shao-Tuan ChenGeorge G Malliaras
Oct 30, 2020·Science Advances·Arijit GhoshFlorin M Selaru
Nov 17, 2020·Macromolecular Bioscience·Anna Herland, Myung-Han Yoon
Sep 29, 2020·Advanced Drug Delivery Reviews·Dinorath Olvera, Michael G Monaghan
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