A microstructurally motivated model of the mechanical behavior of tissue engineered blood vessels.

Annals of Biomedical Engineering
Shannon L M DahlLaura E Niklason

Abstract

Mechanical models have potential to guide the development and use of engineered blood vessels as well as other engineered tissues. This paper presents a microstructurally motivated, pseudoelastic, mechanical model of the biaxial mechanics of engineered vessels in the physiologic pressure range. The model incorporates experimentally measured densities and alignments of engineered collagen. Specifically, these microstructural and associated mechanical inputs were measured directly from engineered blood vessels that were cultured over periods of 5-7.5 weeks. To the best of our knowledge, this is the first successful application of either a phenomenological or a microstructurally motivated mechanical model to engineered vascular tissues. Model development revealed the need to use novel theoretical configurations to describe the strain history of engineered vessels. The constitutive equations developed herein suggested that collagen remodeled between 5 and 7.5 weeks during a 7.5-week culture period. This remodeling led to strain energies for collagen that differed with alignment, which likely resulted from undulations that varied with alignment. Finally, biaxial data emphasized that axial extensions increase stresses in engineered v...Continue Reading

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Jun 15, 2007·Annals of Biomedical Engineering·Shannon L M DahlLaura E Niklason

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Citations

Jul 19, 2013·Biomaterials·Huan ChenGhassan S Kassab
Dec 4, 2009·Proceedings of the National Academy of Sciences of the United States of America·Laura E NiklasonJay D Humphrey
Aug 15, 2012·Tissue Engineering. Part C, Methods·Marijke A A van VlimmerenFrank P T Baaijens
May 7, 2014·Annual Review of Chemical and Biomolecular Engineering·Victor D Varner, Celeste M Nelson
Sep 20, 2011·Journal of the Mechanics and Physics of Solids·Huan ChenGhassan S Kassab
Jan 4, 2015·Biomechanics and Modeling in Mechanobiology·Jin-Jia Hu
Dec 1, 2017·Pediatric Nephrology : Journal of the International Pediatric Nephrology Association·Wee-Song Yeo, Qin Xiang Ng
Aug 12, 2009·The International Journal of Artificial Organs·Umber CheemaRobert A Brown
Apr 26, 2016·Tissue Engineering. Part C, Methods·Angela H HuangLaura E Niklason
Apr 30, 2021·Tissue Engineering. Part C, Methods·Zhang WenZhanyi Lin

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