A microvenular hemangioma with a rare expression of progesterone receptor immunocreativity and a review of the literature

Journal of Cutaneous Pathology
Yi-Chen JuanTsu-Man Chiu

Abstract

Microvenular hemangioma (MVH) is a rare benign vascular tumor with a controversial etiology, but hormone receptor alterations might be involved. We report a case of MVH in a 41-year-old Taiwanese woman who presented with a 1.5 × 1 cm violaceous plaque on left thigh that had appeared 1 year previously. She had taken oral contraceptives for several years and stopped 1 year prior to presentation. Histologically, the tumor was composed of small and compressed venous structures infiltrating in the dermis and subcutis. Immunohistochemically, the tumor cells displayed negative immunoreactivity for human herpesvirus-8 and positive immunoreactivity for smooth muscle actin and progesterone receptor (PR). Taken together with the patient's medical hormone therapy history and the evidence of PR immunoreactivity, our findings support that progesterone may be associated with the tumorigenesis of MVH.

References

Aug 1, 1991·Journal of Cutaneous Pathology·S J HuntR J Barr
May 1, 1995·Clinical and Experimental Dermatology·R J BlackD J Eedy
May 20, 1998·Pathology International·M Fukunaga, S Ushigome
Dec 3, 1999·The British Journal of Dermatology·W RikihisaM Asahi
Feb 20, 2003·Dermatology : International Journal for Clinical and Investigative Dermatology·Y-C KimY-W Cinn
Jun 6, 2003·Pediatric Dermatology·Sung-Eun ChangGhil-Suk Yoon
Jul 27, 2005·The Journal of Dermatology·Christina StefanakiSofia Georgala
Jun 26, 2007·Dermatology : International Journal for Clinical and Investigative Dermatology·Massimiliano ScalvenziAnna Balato
Jul 25, 2008·Pathology, Research and Practice·Angel Fernandez-Flores
Dec 9, 2008·Journal of Plastic, Reconstructive & Aesthetic Surgery : JPRAS·Hiroki MiyashitaKazuyuki Tanaka
May 22, 2009·Clinical and Experimental Dermatology·D R BerkS J Bayliss
Jun 23, 2012·The American Journal of Dermatopathology·Konstantinos LinosJ Andrew Carlson
Nov 22, 2012·The American Journal of Dermatopathology·Felicidade TrindadeIsabel Colmenero
Dec 19, 2013·Oncology Letters·Dong Fang AiPing Li
Aug 21, 2014·Acta Dermato-venereologica·Philipp-Sebastian KochWiebke K Peitsch
Sep 30, 2014·Journal of Cutaneous Pathology·Karl M NapekoskiSteven D Billings

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