A mild catalytic system for radical conjugate addition of nitrogen heterocycles

Chemical Science
R A AycockNathan T Jui

Abstract

The direct addition of pyridine and diazine units to electron-poor alkenes has been achieved via a redox radical mechanism that is enabled by limiting the effective concentration of the hydrogen-atom source. The described method is tolerant of acidic functional groups and is generally applicable to the union of a wide range of Michael acceptors and 6-membered heterocyclic halides.

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Citations

Apr 6, 2018·Chemical Science·R A AycockN T Jui
Jul 4, 2019·Organic & Biomolecular Chemistry·Peng-Zi WangWen-Jing Xiao
Aug 11, 2019·Angewandte Chemie·J Luke KoniarczykAndrew McNally
Apr 25, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Andrea MenichettiMauro Pineschi
Jun 15, 2019·Chemical Communications : Chem Comm·Rebecca J WilesGary A Molander
May 1, 2021·Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry·Benjamin T BoyleAndrew McNally
Jun 3, 2021·Chemical Communications : Chem Comm·Haoyu LiShunsuke Chiba
Jun 10, 2021·Journal of the American Chemical Society·Cecilia M HendyNathan T Jui
Jul 31, 2021·Synlett : Accounts and Rapid Communications in Synthetic Organic Chemistry·Racheal M SpurlinNathan T Jui
May 8, 2020·Journal of the American Chemical Society·Autumn R FlynnNathan T Jui
May 5, 2017·Journal of the American Chemical Society·Allyson J BoyingtonNathan T Jui
Oct 24, 2018·Organic Letters·Thomas RossoliniDarren J Dixon
Oct 26, 2018·Journal of the American Chemical Society·Ciaran P SeathNathan T Jui
Feb 14, 2019·Journal of the American Chemical Society·Allyson J BoyingtonNathan T Jui
Oct 8, 2021·The Journal of Organic Chemistry·Hehuan XuZhiyong Jiang
Dec 30, 2021·Organic Letters·Minseok KimSungwoo Hong

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