A mildly inducible and selective cross-link methodology for RNA duplexes

Organic & Biomolecular Chemistry
Lieselot L G CarretteAnnemieke Madder

Abstract

We here report on the furan oxidation methodology for interstrand cross-linking of RNA duplexes, which have a different structure and are more stiff, reactive and labile than their DNA counterparts. Through this mildly inducible approach, natural unmodified RNA can be selectively cross-linked in high yield. The method therefore has direct applications in the increasing number of RNA based technologies.

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Citations

Jun 13, 2014·Organic & Biomolecular Chemistry·Jens M Stadler, Thorsten Stafforst
Oct 16, 2014·Chemical Communications : Chem Comm·Tamsyn MontagnonGeorgios Vassilikogiannakis
Oct 9, 2014·The Journal of Organic Chemistry·Jack L Sloane, Marc M Greenberg
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Dec 30, 2016·The Journal of Organic Chemistry·Ransheng DingChristian Wolf
Jan 4, 2017·Chemistry : a European Journal·Fabian MuttachAndrea Rentmeister
Jun 6, 2019·Beilstein Journal of Organic Chemistry·Shahien ShahsavariShiyue Fang
Sep 6, 2020·Chembiochem : a European Journal of Chemical Biology·Penthip Muangkaew, Tirayut Vilaivan
Jul 12, 2021·Bioorganic & Medicinal Chemistry Letters·Ahmed Mostafa AbdelhadyFumi Nagatsugi
Jul 18, 2017·ACS Chemical Biology·Willem VanneckeAnnemieke Madder
Sep 22, 2021·Chemical Reviews·Vivian M LechnerMatthew J Gaunt

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