A miniature, single use, skin-adhered, low-voltage, electroosmotic pumping-based subcutaneous infusion system

Drug Delivery and Translational Research
Woonsup ShinAdam Heller

Abstract

A programmable, skin-attached, 36 × 30 × 8 mm system for subcutaneous infusion of 1.2 mL of a drug solution is described. The system is intended to be replaced daily. It comprises a 20 × 14 × 8 mm electronic controller and power source, an 8 mm diameter 2 mm thick electroosmotic pump, a two-compartment reservoir for a pumped water and a drug solution, an adhesive tape for attachment to the skin, and a 6 mm long 27 gauge needle. Its removable electronic controller programs the dose rate and dose and is re-used. The electroosmotic pump consists of a porous ceramic membrane sandwiched between a pair of Ag/Ag2O plated carbon paper electrodes. It operates below 1.23 V, the thermodynamic threshold for water electrolysis without gassing. The flow rate can be adjusted between 4 and 30 μL min(-1) by setting either by the voltage (0.2-0.8 V) or the current (30-200 μA). For average flow rates below 4 μL min(-1), the pump is turned on and off intermittently. For example, a flow rate of 160 μL day(-1), i.e., 0.13 μL min(-1) for basal insulin infusion in type 1 diabetes management, is obtained when 10 s pulses of 75 μA is applied every 15 min. High flow rates of 10-30 μL min(-1), required for prandial insulin administration, are obtained whe...Continue Reading

References

May 2, 2007·The Analyst·Fu-Qiang NieBrett Paull
Nov 11, 2008·Nature Biotechnology·Mark R Prausnitz, Robert Langer
Feb 7, 2009·Journal of the American Pharmacists Association : JAPhA·Lakshmi G Potti, Stuart T Haines
Nov 26, 2009·Biomedical Microdevices·Allan Thomas EvansYogesh B Gianchandani
May 12, 2010·Journal of Clinical Pharmacy and Therapeutics·F M AlsalehK M G Taylor
Dec 7, 2010·Therapeutic Delivery·Kalpana S PaudelAudra L Stinchcomb
Feb 9, 2011·Journal of the American Chemical Society·Woonsup ShinAdam Heller

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Citations

Dec 10, 2014·Journal of Laboratory Automation·Yi LuPak Kin Wong
Jan 26, 2021·Langmuir : the ACS Journal of Surfaces and Colloids·Sooraj SreenathRajaram K Nagarale

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