A miniaturized rapid paper chromatographic procedure for quality control of technetium-99m sestamibi

European Journal of Nuclear Medicine
M PatelA Owunwanne

Abstract

A miniaturized rapid paper chromatographic technique (MRPC) for quality control of a technetium-99m sestamibi preparation was developed and compared with the manufacturer's and Hung et al. techniques. The MRPC system involves the use of 6.0x0.5cm Whatman 3MM paper strip developed in ethyl acetate. The procedure was completed within 3min while that of the manufacturer and Hung techniques took 30-35 and 4min respectively. The Rf range of 99mTc-sestamibi using MRPC was 0.55-0.75 while that of the other two techniques was 0.9-1.0. The results indicate that MRPC can be used to separate 99mTc-sestamibi from any 99mTc contaminant that migrates with the solvent front. The MRPC is a fast and effective chromatographic technique for routine quality control testing of 99mTc-sestamibi preparation.

References

Sep 1, 1992·Nuclear Medicine Communications·R M ReillyS Houle
Feb 1, 1990·Fundamental and Applied Toxicology : Official Journal of the Society of Toxicology·R S ChhabraR A Renne
Jan 1, 1994·European Journal of Nuclear Medicine·H M Abdel-DayemS Larson

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Citations

Aug 2, 2012·International Journal of Radiation Biology·Marcia de Oliveira PereiraMario Bernardo-Filho
Mar 22, 2018·Nuclear Medicine Communications·Manuel Montoza-AguadoCarmen Puentes-Zarzuela

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