A miR-124/ITGA3 axis contributes to colorectal cancer metastasis by regulating anoikis susceptibility

Biochemical and Biophysical Research Communications
Ke-di SaJian-Yong Sun

Abstract

Metastasis is the major cause for the death of patients with colorectal cancer (CRC). Anoikis resistance enhances the survival of cancer cells during systemic circulation, thereby facilitating secondary tumor formation in distant organs. miR-124 is a pleiotropically tumor suppressive small non-coding molecule. However, its role and mechanism in the regulation of cancer cell anoikis are still unknown. Here, we found that overexpression of miR-124 promotes anoikis of CRC cells in vitro and in vivo. In silico analysis and the experimental evidence supported that ITGA3 is a bona fide target of miR-124. Moreover, we identifies that ITGA3 plays a critical role in the regulation of anoikis sensitivity in CRC cells. Finally, our analysis in TCGA datasets demonstrates that high levels of ITGA3 are closely associated with poor prognosis in CRC patients. Collectively, we establish a functional link between miR-124 and anoikis susceptibility and provide that a miR-124/ITGA3 axis could be a potential target for the treatment of metastatic CRC.

Citations

Oct 9, 2019·British Journal of Biomedical Science·P Waller, A D Blann
Jan 3, 2021·Cellular Signalling·Neda YaghoubiSeyed Hamid Aghaee-Bakhtiari
Feb 11, 2021·International Journal of Molecular Sciences·Andrea AngiusMaria Rosaria De Miglio
Nov 6, 2020·OncoTargets and Therapy·Xiang-Qiong WenJia-Ping Hu
Jan 14, 2021·International Journal of Molecular Sciences·Han Yeoung LeeJong Kook Park

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