A Missense Variant in TREML2 Reduces Risk of Alzheimer's Disease in a Han Chinese Population

Molecular Neurobiology
Teng JiangJin-Tai Yu

Abstract

Recently, Benitez and colleagues re-analyzed whole-exome sequencing data and revealed that a coding missense variant (rs3747742-C) in triggering receptor expressed on myeloid cells-like 2 (TREML2) gene reduced late-onset Alzheimer's disease (LOAD) risk in Caucasians. To date, no study was carried out to test this association in other ethnic groups and populations, including Han Chinese. Therefore, the aim of the current study was to validate the relation between rs3747742 and LOAD susceptibility in a large Han Chinese population including 992 LOAD patients and 1358 healthy controls. In the total sample, the minor (C) allele of rs3747742 was associated with a reduced LOAD risk under the recessive genetic model after Bonferroni correction (odds ratio (OR) = 0.713; 95 % confidence interval (CI): 0.546-0.932; P = 0.013, Bonferroni-corrected P = 0.039). Interestingly, after stratifying data according to apolipoprotein E (APOE) ε4 status, we revealed that this protection only exists in APOE ε4 carriers (recessive genetic model, OR = 0.448; 95 % CI: 0.262-0.765; P = 0.003, Bonferroni-corrected P = 0.009) in our cohort. Taken together, our findings support rs3747742-C as a protective factor for LOAD, especially in APOE ε4 carriers.

References

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Oct 8, 2013·Neurobiology of Aging·Teng JiangLan Tan
Oct 15, 2013·Neurobiology of Aging·Elise CuyversUNKNOWN BELNEU consortium
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Citations

Oct 22, 2016·Acta Neuropathologica·Teng JiangJin-Tai Yu
Nov 14, 2019·Neurotoxicity Research·Yue-Song LiuUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Feb 20, 2020·Brain and Behavior·Si-Yu WangUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Jun 4, 2019·Frontiers in Neuroscience·Ya-Nan SongUNKNOWN Alzheimer’s Disease Neuroimaging Initiative
Mar 10, 2020·Journal of Hypertension·Guijiang WeiYesheng Wei
Jun 23, 2020·Journal of Alzheimer's Disease : JAD·Si-Yu WangTeng Jiang
Oct 23, 2020·Alzheimer's & Dementia : the Journal of the Alzheimer's Association·Daniel L KoberTom J Brett

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Methods Mentioned

BETA
genotyping

Software Mentioned

STPLAN
SPSS

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