A mitochondria-targeting hetero-binuclear Ir(iii)-Pt(ii) complex induces necrosis in cisplatin-resistant tumor cells

Chemical Communications : Chem Comm
Cheng OuyangHui Chao

Abstract

A hetero-binuclear Ir(iii)-Pt(ii) complex was developed as an antitumor agent. In vitro cytotoxicity results indicated that this complex was effective against cisplatin-resistant tumor cells. Mechanism experiments showed that it can overcome cisplatin resistance by increasing cellular uptake, targeting mitochondria, and inducing cell necrosis.

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Citations

Oct 3, 2019·Dalton Transactions : an International Journal of Inorganic Chemistry·Qi-Pin QinHong Liang
Dec 20, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sascha G KellerYasuteru Urano
Sep 22, 2020·The Journal of Nutritional Biochemistry·Run LiuJiankang Liu
Aug 18, 2021·Drug Resistance Updates : Reviews and Commentaries in Antimicrobial and Anticancer Chemotherapy·Andreia ValentePetra Heffeter
Oct 6, 2021·Chemical Communications : Chem Comm·Xiangjie LuoJinhao Gao

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Methods Mentioned

BETA
flow cytometry
confocal microscopy
flow
PCR

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