A mitochondrially encoded hormone ameliorates obesity and insulin resistance

Cell Metabolism
Kim Zarse, Michael Ristow

Abstract

MOTS-c, a mitochondrially encoded open reading frame-derived peptide recently discovered by Lee et al. 2015 (this issue of Cell Metabolism) promotes biosynthesis of an endogenous AMP analog, AICAR. As AICAR activates AMPK, the discovery of MOTS-c offers an unexpected therapeutic option to be exploited toward the prevention of type 2 diabetes and delaying of the aging processes.

References


❮ Previous
Next ❯

Citations

Oct 7, 2015·Trends in Pharmacological Sciences·Shunchang Li, Ismail Laher
May 1, 2016·Cell Calcium·Roberta A Gottlieb, Daniel Bernstein
May 25, 2016·Free Radical Biology & Medicine·Changhan LeePinchas Cohen
May 31, 2016·Biochemical and Biophysical Research Communications·Wei MingLu Zifan
Jun 30, 2018·The Journals of Gerontology. Series A, Biological Sciences and Medical Sciences·Maria ConteStefano Salvioli
Aug 6, 2019·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·Bérénice A Benayoun, Changhan Lee
Aug 15, 2018·Cells·Cheryl Qian Ying Yong, Bor Luen Tang
Aug 7, 2020·Seminars in Immunopathology·Maria ConteStefano Salvioli
Feb 24, 2019·Proceedings of the National Academy of Sciences of the United States of America·Anastasia ChugunovaOlga Dontsova
Mar 7, 2017·Frontiers in Endocrinology·Indranil SinhaDavid E Varon
Oct 28, 2020·The Journal of Biological Chemistry·Daniel L MorrisNico Tjandra
Jan 5, 2021·Sleep & Breathing = Schlaf & Atmung·Filiz Alkan Baylan, Esra Yarar
Jan 18, 2021·The Journal of Biological Chemistry·Daniel L MorrisNico Tjandra
Mar 21, 2021·Seminars in Cell & Developmental Biology·Jyung Mean Son, Changhan Lee
Jun 10, 2021·Nature Reviews. Drug Discovery·Carolina Gubert, Anthony J Hannan

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cardiovascular Disease Pathophysiology

Cardiovascular disease involves several different processes that contribute to the pathological mechanism, including hyperglycemia, inflammation, atherosclerosis, hypertension and more. Vasculature stability plays a critical role in the development of the disease. Discover the latest research on cardiovascular disease pathophysiology here.

CV Disorders & Type 2 Diabetes

This feed focuses on the association of cardiovascular diseases in patients with type 2 diabetes.

Cancer Metabolism

In order for cancer cells to maintain rapid, uncontrolled cell proliferation, they must acquire a source of energy. Cancer cells acquire metabolic energy from their surrounding environment and utilize the host cell nutrients to do so. Here is the latest research on cancer metabolism.