PMID: 8594045Nov 1, 1995Paper

A model analysis of asymmetrical response of pulmonary VO2 during incremental and decremental ramp exercise

Journal of Applied Physiology
K NiizekiY Miyamoto

Abstract

The responses of gas exchange and ventilatory variables exhibit obvious asymmetry between the incremental and decremental phases of trapezoidal ramp exercise (29). Computer simulation was performed to explore the possible mechanisms producing this asymmetry of pulmonary O2 uptake (VO2) dynamics. The model consisted of three compartments (the lungs, the exercising muscles, and the other organs and tissues), which were perfused by respective regional circulations. Exercise was simulated by increasing the pulmonary blood flow (Q) and the muscle. VO2 in proportion to work rate. The dynamic responses of Q and the muscle VO2 were assumed to obey first-order linear kinetics. The ratio of blood flow in the muscle compartment to total cardiac output was assumed to increase linearly with work rate. Our simulation demonstrated that the muscle blood flow and mixed venous O2 content exhibited significant asymmetry between the incremental and decremental phases of exercise. The model suggested that the asymmetry of VO2 between incremental and decremental ramp exercise was dependent on the redistribution ratio of blood flow to the working muscles. The validity of the model was then evaluated by comparing the simulated results with experimenta...Continue Reading

Citations

Dec 5, 2012·Journal of Sports Sciences·R Hugh Morton, Veronique Billat
Jul 4, 2012·European Journal of Applied Physiology·Véronique BillatLaurence Mille-Hamard
Dec 11, 2007·Scandinavian Journal of Medicine & Science in Sports·A M JonesM Burnley

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.

© 2021 Meta ULC. All rights reserved