A model-based analysis of autonomic nervous function in response to the Valsalva maneuver

Journal of Applied Physiology
E Benjamin RandallMette S Olufsen

Abstract

The Valsalva maneuver (VM) is a diagnostic protocol examining sympathetic and parasympathetic activity in patients with autonomic dysfunction (AD) impacting cardiovascular control. Because direct measurement of these signals is costly and invasive, AD is typically assessed indirectly by analyzing heart rate and blood pressure response patterns. This study introduces a mathematical model that can predict sympathetic and parasympathetic dynamics. Our model-based analysis includes two control mechanisms: respiratory sinus arrhythmia (RSA) and the baroreceptor reflex (baroreflex). The RSA submodel integrates an electrocardiogram-derived respiratory signal with intrathoracic pressure, and the baroreflex submodel differentiates aortic and carotid baroreceptor regions. Patient-specific afferent and efferent signals are determined for 34 control subjects and 5 AD patients, estimating parameters fitting the model output to heart rate data. Results show that inclusion of RSA and distinguishing aortic/carotid regions are necessary to model the heart rate response to the VM. Comparing control subjects to patients shows that RSA and baroreflex responses are significantly diminished. This study compares estimated parameter values from the mo...Continue Reading

References

Mar 1, 1976·Journal of Applied Physiology·P I KornerJ B Uther
Jan 1, 1989·The American Journal of Physiology·R D BergerR J Cohen
Sep 1, 1987·The American Journal of Physiology·R W deBoerJ Strackee
Jan 1, 1985·The American Journal of Physiology·B PomeranzR J Cohen
Apr 1, 1970·Cardiovascular Research·A D Jose, D Collison
Nov 1, 1981·Clinical Science·G L JenningsP I Korner
Apr 1, 1995·The American Journal of Physiology·N Craft, J B Schwartz
Feb 1, 1993·Acta Physiologica Scandinavica·T MetsäläI Välimäki
Sep 1, 1996·The American Journal of Cardiology·J KautznerM Malik
Sep 1, 1996·The American Journal of Physiology·M L SmithD L Eckberg
Oct 24, 1998·Computers in Biology and Medicine·J BaiX Zhou
Dec 9, 1998·Applied Human Science : Journal of Physiological Anthropology·H Kobayashi
Jan 12, 2001·Journal of the American College of Cardiology·H TanakaD R Seals
Jul 14, 2001·Journal of Cardiovascular Pharmacology and Therapeutics·W W Nichols, D G Edwards
Nov 16, 2001·American Journal of Physiology. Heart and Circulatory Physiology·K LuA Bidani
Aug 23, 2003·Journal of Neurology, Neurosurgery, and Psychiatry·Christopher J Mathias
Oct 6, 2005·Computers in Biology and Medicine·C De LazzariG Tosti
Nov 5, 2005·Sleep·Robert Joseph ThomasAry L Goldberger
Jun 24, 2006·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Mette S OlufsenVera Novak
Mar 14, 2007·Archives of Neurology·Christine SchrezenmaierPhillip A Low
Apr 20, 2007·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Kevin D Monahan
Dec 18, 2007·Cardiovascular Engineering·Laura M EllweinMette S Olufsen
Mar 19, 2009·Mathematical Biosciences and Engineering : MBE·Scott R PopeMette S Olufsen
Apr 28, 2011·Biomedical Engineering Online·Yubing ShiRodney Hose
Jul 27, 2011·Journal of Visualized Experiments : JoVE·Peter Novak
Mar 1, 2010·Archives of Medical Science : AMS·Agnieszka Zygmunt, Jerzy Stanczyk
May 17, 2012·Journal of Mathematical Biology·Mette S Olufsen, Johnny T Ottesen
Nov 20, 2012·Proceedings of the Institution of Mechanical Engineers. Part H, Journal of Engineering in Medicine·Jinhuai LinDerek G Tilley
Nov 28, 2012·Netherlands Heart Journal : Monthly Journal of the Netherlands Society of Cardiology and the Netherlands Heart Foundation·C A Swenne
Aug 13, 2013·Handbook of Clinical Neurology·Roy Freeman, Mark W Chapleau
Aug 21, 2013·Mathematical Medicine and Biology : a Journal of the IMA·Nakeya D WilliamsMette S Olufsen
Oct 11, 2013·Conference Proceedings : ... Annual International Conference of the IEEE Engineering in Medicine and Biology Society·Virginie Le RolleAlfredo I Hernández
Nov 23, 2013·Parkinsonism & Related Disorders·Jose-Alberto Palma, Horacio Kaufmann
Dec 19, 2013·PLoS Computational Biology·Adam MahdiMette S Olufsen
Sep 10, 2014·Journal of Electrocardiology·Eric HelfenbeinSaeed Babaeizadeh
Jan 1, 2015·Annals of Biomedical Engineering·Greg MaderAdam Mahdi

❮ Previous
Next ❯

Citations

Feb 15, 2021·Medical & Biological Engineering & Computing·Steven GilmoreMette S Olufsen
Dec 1, 2019·Mathematical Biosciences·E Benjamin RandallMette S Olufsen
May 14, 2021·Journal of Theoretical Biology·E Benjamin RandallMette S Olufsen

❮ Previous
Next ❯

Methods Mentioned

BETA
RSA

Software Mentioned

LabChart
RADAR5
MATLAB

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.