A model-based evaluation of single metrics for discriminating changes in rheumatoid arthritis disease activity

British Journal of Clinical Pharmacology
Jessica WojciechowskiRichard N Upton

Abstract

Composite indices for quantifying rheumatoid arthritis (RA) disease activity such as the 28-joint disease activity score (DAS28) are comprised of single parameters ('metrics') in various combinations. Population modelling methods were used to evaluate single metrics for their ability to reflect changes in disease activity with a view to understanding and improving composite indices. A total of 11 single metrics of RA disease activity (tender and swollen joint counts, acute phase reactants and global health, pain and physical function assessments) were obtained from 203 patients with recent onset RA. Participants received combination disease-modifying anti-rheumatic drugs (DMARDs) according to a treat-to-target approach with a pre-defined protocol for treatment intensification. Models describing each metric's magnitude and variability of change from baseline to a single 'treated' state in the population were developed using nonmem(®) . Measures that displayed uniformly large changes between states across the population were ranked higher in terms of discriminatory capacity. Joint counts demonstrated a greater ability to discriminate changes in RA disease activity than others. Correlations between metrics demonstrated that erythr...Continue Reading

References

Feb 1, 1992·Annals of the Rheumatic Diseases·D M van der HeijdeL B van de Putte
Dec 16, 1998·British Journal of Rheumatology·A A StengerM H van Rijswijk
Mar 11, 2010·Annals of the Rheumatic Diseases·Josef S SmolenUNKNOWN T2T Expert Committee
Feb 9, 2011·The AAPS Journal·Martin BergstrandMats O Karlsson
Jun 21, 2014·The AAPS Journal·Diane R MouldJessica Wojciechowski
Nov 14, 2014·British Journal of Clinical Pharmacology·Jessica WojciechowskiRichard N Upton

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