PMID: 43719May 1, 1979

A model enzymic extracorporeal detoxification system

Artificial Organs
S S SoferB J Van Wie

Abstract

Preliminary studies at the University of Oklahoma have incorporated the use of a continuous, seal-less blood centrifuge as an extracorporeal detoxification unit to aid in the removal of foreign chemicals from the blood. Detoxification is performed by immobilized enzymes in conjunction with a cofactor (NADPH) bound to a water-soluble macromolecule. A drug enters the device with the plasma and then passes across a semipermeable membrane which serves to retain the cofactor. At this point, a combination of the drug, the cofactor and the enzyme react to form the drug-oxide. The oxide then passes back through the membrane into the blood and back into the body. Concurrently, the macro-NADP+ is reduced by G-6-P and G-6-PD in the cofactor regeneration portion of the device. To facilitate detoxification, the centrifuge is employed to provide plasma rich in toxins, but void of potentially interfering blood components such as platelets and whole blood cells. These components tend to dilute the toxins or adhere to the interfacing membrane, decreasing the permeability of these toxins into the detoxification unit. It is felt that the centrifuge-detoxification combination will provide a potentially efficient hepatic assist device.

References

Feb 1, 1976·Journal of Medicinal Chemistry·I ParikhC Fenselau
Sep 14, 1968·Lancet·S C BosmanC N Barnard
Feb 1, 1973·Journal of Applied Physiology·C HorvathJ S Woods
Jul 1, 1973·American Journal of Surgery·T SoyerB Eiseman
Feb 16, 1972·Biochemical and Biophysical Research Communications·A Y Lu, W Levin
Apr 14, 1972·Biochemical and Biophysical Research Communications·J P AllisonG B Kitto
Sep 1, 1965·Annals of Surgery·B EisemanF Raffucci
Dec 1, 1970·Journal of Biomedical Materials Research·H H Weetall
Apr 15, 1971·The New England Journal of Medicine·J L RosenbaumC Boreyko
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Nov 1, 1963·Annals of Surgery·J D STEWARTT DRAPANAS

Citations

May 1, 1979·Artificial Organs·K D Kulbe

Related Concepts

Aniline Compounds
Artificial Organs
Centrifugation
Trachyl
Extracorporeal Circulation
Liver
Membranes, Artificial
NADP
Permeability

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