A model for binaural response properties of inferior colliculus neurons. II. A model with interaural time difference-sensitive excitatory and inhibitory inputs and an adaptation mechanism

The Journal of the Acoustical Society of America
H CaiH Steven Colburn

Abstract

The inferior colliculus (IC) model of Cai et al. [J. Acoust. Soc. Am. 103, 475-493 (1998)] simulated the binaural response properties of low-frequency IC neurons in response to various acoustic stimuli. This model, however, failed to simulate the sensitivities of IC neurons to dynamically changing temporal features, such as the sharpened dynamic interaural phase difference (IPD) functions. In this paper, the Cai et al. (1998) model is modified such that an adaptation mechanism, viz., an additional channel simulating a calcium-activated, voltage-independent potassium channel which is responsible for afterhyperpolarization, is incorporated in the IC membrane model. Simulations were repeated with this modified model, including the responses to pure tones, binaural beat stimuli, interaural phase-modulated stimuli, binaural clicks, and pairs of binaural clicks. The discharge patterns of the model in response to current injection were also studied and compared with physiological data. It was demonstrated that this model showed all the properties that were simulated by the Cai et al. (1998) model. In addition, it showed some properties that were not simulated by that model, such as the sharpened dynamic IPD functions and adapting disc...Continue Reading

References

Feb 1, 1978·The Journal of the Acoustical Society of America·D W Grantham, F L Wightman
May 1, 1985·Proceedings of the National Academy of Sciences of the United States of America·P PennefatherR A Nicoll
Feb 1, 1982·Proceedings of the National Academy of Sciences of the United States of America·M HuguesM Lazdunski
Jan 10, 1984·The Journal of Comparative Neurology·D L Oliver, D K Morest
Oct 1, 1982·The Journal of the Acoustical Society of America·D W Grantham
Feb 1, 1994·The Journal of Comparative Neurology·D L OliverR L Saint Marie
Jan 1, 1993·The Journal of the Acoustical Society of America·L H Carney
Dec 1, 1995·Journal of Neurophysiology·D C FitzpatrickC Trahiotis
Nov 1, 1963·Journal of Neurophysiology·P G NELSON, S D ERULKAR

❮ Previous
Next ❯

Citations

Jan 25, 2013·Journal of Comparative Physiology. A, Neuroethology, Sensory, Neural, and Behavioral Physiology·Abhilash PonnathHamilton E Farris
Oct 23, 2008·Journal of the Association for Research in Otolaryngology : JARO·H Steven ColburnAndrew Brughera
Oct 3, 2006·Nature Neuroscience·Ilana B WittenEric I Knudsen
Jan 24, 2009·Journal of Neurophysiology·Brian H ScottMalcolm N Semple
Aug 5, 2005·Journal of Neurophysiology·Donal G SinexDavid S Velenovsky
Dec 7, 2013·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Yunyan Wang, José Luis Peña
May 2, 2014·Frontiers in Physiology·Yunyan WangJosé L Peña
Dec 17, 2014·PloS One·Steven SkorheimMaxim Bazhenov
Oct 26, 1999·The Journal of the Acoustical Society of America·R Y LitovskyS J Guzman
Oct 10, 2003·Journal of Neurophysiology·Neil J Ingham, David McAlpine
Jul 19, 2017·Journal of the Association for Research in Otolaryngology : JARO·Kenneth E HancockBertrand Delgutte
Jul 9, 2004·The Journal of the Acoustical Society of America·Michael F Neelon, Rick L Jenison
Aug 29, 2019·Journal of Neurophysiology·Nathaniel J Zuk, Bertrand Delgutte
Sep 3, 2020·The Journal of the Acoustical Society of America·Jonas KlugMathias Dietz

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.