PMID: 991271Nov 1, 1976Paper

A model for chromatin based upon two symmetrically paired half-nucleosomes

Cell
H WeintraubB Alberts

Abstract

We propose that the basic unit of chromatin is constructed of two isologously paired heterotypic protein tetramers each containing one molecule of H2A, H2B, H3, and H4 histone. These proteins form a core that holds 140 base pairs (bp) of DNA in a single left-handed, non-interwound DNA super-coil approximately 95 bp in circumference, creating a nucleosome particle (DNA and protein) organized about a dyad axis of symmetry. Such a nucleosome can open up into its separate half-nucleosomes to allow genetic readout without requiring histone displacement.

Citations

Nov 1, 1977·Die Naturwissenschaften·F Lampert
Dec 31, 1980·Molecular Biology Reports·H T Khachatrian, V A Pospelov
Jun 30, 1982·Biochemical and Biophysical Research Communications·A Nishio, E M Uyeki
Jan 1, 1991·The International Journal of Biochemistry·U Pfeffer, G Vidali
Feb 1, 1979·Mechanisms of Ageing and Development·R W HartS P Modak
Jan 1, 1977·Progress in Biophysics and Molecular Biology·J P Goddard
Apr 1, 1980·Biophysical Chemistry·J A Harpst
Aug 1, 1984·Biophysical Chemistry·G MithieuxC Marion
Jan 1, 1980·Bio Systems·A D MirzabekovV V Shick
Jan 12, 1978·Nature·G Felsenfeld
Feb 16, 2011·Cell Research·Bing Zhu, Danny Reinberg
Oct 24, 2009·Nature Reviews. Molecular Cell Biology·Shahragim Tajbakhsh, Cayetano Gonzalez
Dec 15, 1977·The New England Journal of Medicine·A W Nienhuis, E J Benz
Nov 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·A GarelR Axel
Dec 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·R D Camerini-Otero, G Felsenfeld
Jan 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·J L Sussman, E N Trifonov
Feb 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V C GordonV N Schumaker
Mar 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·E M JohnsonH R Matthews
Aug 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C W Carter
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·V SasisekharanG Gupta
Mar 1, 1979·Proceedings of the National Academy of Sciences of the United States of America·A D Mirzabekov, A Rich
Mar 1, 1981·Proceedings of the National Academy of Sciences of the United States of America·A WorcelD Riley
Jul 1, 1993·Proceedings of the National Academy of Sciences of the United States of America·T E O'NeillE M Bradbury
Aug 1, 1981·The Journal of Cell Biology·J AllanH Gould
Dec 11, 1990·Nucleic Acids Research·L LocklearJ R Davie
Oct 1, 1977·Nucleic Acids Research·R E Harrington
Nov 1, 1977·Nucleic Acids Research·B Wittig, S Wittig
Jan 1, 1977·Nucleic Acids Research·R D Camerini-Otero, G Felsenfeld
Jun 1, 1977·Nucleic Acids Research·D E OlinsA L Olins
Jun 1, 1977·Nucleic Acids Research·D M Lilley, K Tatchell
Oct 1, 1978·Nucleic Acids Research·D R BurtonI O Walker
Apr 1, 1978·Nucleic Acids Research·E Trifonov
Jun 1, 1978·Nucleic Acids Research·L K KaragyozovA A Hadjiolov
Jul 1, 1978·Nucleic Acids Research·V L Seligy, N H Poon
Aug 1, 1978·Nucleic Acids Research·P A ShawG F Saunders
Sep 25, 1979·Nucleic Acids Research·D M LilleyM Houghton
Nov 25, 1980·Nucleic Acids Research·H J GouldJ Allan

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