A model for differential volatile anesthetic delivery to the upper and lower torso of the rabbit

Journal of Pharmacological and Toxicological Methods
Richard AtherleyEarl Carstens

Abstract

We have developed a model that permits differential delivery of volatile anesthetics to the upper and lower torso of the rabbit. Rabbits were anesthetized with isoflurane (n = 4) or halothane (n = 3), and blood was drained from a carotid cannula into a membrane oxygenator and reinfused via a renal artery cannula into the lower torso circulation using a roller pump. Bypass of the lower torso circulation was achieved by tightening a ligature around the aorta at the level of the renal arteries. Blood concentrations of anesthetic (assessed by gas chromatography) and cardiovascular responses to noxious stimulation were determined with and without anesthetic delivery to the membrane oxygenator. When the anesthetic was removed from the oxygenator gas flow, the arterial concentration of isoflurane in the lower torso was 28 +/- 15 microg/ml, while it was 133 +/- 28 microg/ml in the upper torso circulation; the corresponding values for the halothane-anesthetized rabbits were 63 +/- 8 and 270 +/- 49 microg/ml. There was a significant correlation (r=.92-.99) between pump flow and lower torso pressure in each individual rabbit. When anesthetic was delivered to both upper and lower torso, noxious electrical stimulation of the tail or hindpaw...Continue Reading

References

Mar 1, 1980·Stroke; a Journal of Cerebral Circulation·J A Zivin, U DeGirolami
Dec 1, 1993·Anesthesiology·J F Antognini, K Schwartz
Oct 25, 2003·Anesthesiology·Meiko KakimotoNoboru Konishi

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