A model for hematopoietic death in man from irradiation of bone marrow during radioimmunotherapy

The British Journal of Radiology
B R Scott, L E Dillehay

Abstract

There are numerous institutions worldwide performing clinical trials of radioimmunotherapy (RIT) for cancer. For RIT, an exponentially decaying radionuclide is attached by using a chelating agent to a specific monoclonal or polyclonal tumour antibody (e.g. antiferritin IgG). The major limitation to RIT is toxicity to normal tissue in organs other than the one containing the tumour (e.g. bone marrow). The focus of this manuscript is on modelling the risk (or probability) of hematopoietic death in man for exponentially decaying patterns of high-energy beta irradiation (e.g. 90Y) of bone marrow by radioimmunoglobulin injected into the blood. The analytical solutions presented are only applicable to protocols for which significant uptake of radioactivity by the bone marrow does not occur, and only for high energy beta emitters. However, the generic equation used to obtain the analytical solutions is applicable to any continuous pattern of high energy beta irradiation. A model called the "normalized dose model" was used to generate calculated values for the LD50 as a function of the effective half-time for the radioimmunoglobulin in the blood. A less complicated empirical model was used to describe the calculated values. This model ...Continue Reading

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Citations

Jul 24, 2008·Dose-response : a Publication of International Hormesis Society·Bobby R Scott
Mar 8, 2007·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·John HarrisonBobby Scott
May 21, 2009·Journal of Radiological Protection : Official Journal of the Society for Radiological Protection·John Harrison
Mar 1, 2020·Clinical and Translational Science·John HarroldMurad Melhem

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