Mar 19, 2008

A model for mechano-electrical feedback effects on atrial flutter interval variability

Bulletin of Mathematical Biology
Michela MasèF Ravelli


Atrial flutter is a supraventricular arrhythmia, based on a reentrant mechanism mainly confined to the right atrium. Although atrial flutter is considered a regular rhythm, the atrial flutter interval (i.e., the time interval between consecutive atrial activation times) presents a spontaneous beat-to-beat variability, which has been suggested to be related to ventricular contraction and respiration by mechano-electrical feedback. This paper introduces a model to predict atrial activity during atrial flutter, based on the assumption that atrial flutter variability is related to the phase of the reentrant activity in the ventricular and respiratory cycles. Thus, atrial intervals are given as a superimposition of phase-dependent ventricular and respiratory modulations. The model includes a simplified atrioventricular (AV) branch with constant refractoriness and conduction times, which allows the prediction of ventricular activations in a closed-loop with atrial activations. Model predictions are quantitatively compared with real activation series recorded in 12 patients with atrial flutter. The model predicts the time course of both atrial and ventricular time series with a high beat-to-beat agreement, reproducing 96+/-8% and 86+/...Continue Reading

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Mentioned in this Paper

Myocardial Contraction
In Silico
Supraventricular Tachycardia
Cell Respiration
Contraction (Finding)
Feedback - System Communication
Right Atrial Structure
Entire Right Atrium
Respiratory Gaseous Exchange in Organisms

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