PMID: 239114Apr 1, 1975Paper

A model for steroid transport across biological membranes

The Journal of Pharmacy and Pharmacology
A H Beckett, M E Pickup


The absorption of a range of steroids (water soluble to lipid soluble) in the mouth was investigated under standard conditions and using gas chromatography. A two-compartment open model was used to describe the absorption of these steroids into, and through, the membrane. Rate constants were calculated on this basis using a feathering technique, and were used in an analogue computer program to predict steroid concentration which agree favourably with experimental data. Correlations between absorption and partition data were made in an attempt to relate the proposed model to anatomical features of the absorptive membrane and to make comparison with models proposed to describe drug absorption across the intestinal mucosa.


Dec 1, 1972·The Journal of Pharmacy and Pharmacology·T Yotsuyanagi, W I Higuchi
Feb 1, 1968·The Journal of Pharmacy and Pharmacology·R N Beckett AH BOYES, E J Triggs
Dec 1, 1971·The Journal of Pharmacy and Pharmacology·J C Dearden, E Tomlinson
Nov 1, 1972·Journal of Pharmaceutical Sciences·K R VoraN F Ho
Jan 1, 1970·Journal of Pharmaceutical Sciences·J T DoluisioL W Dittert
Jan 1, 1969·The Journal of Investigative Dermatology·R J ScheupleinD J MacFarlane
Oct 1, 1965·The Journal of Clinical Endocrinology and Metabolism·H P Schedl
Aug 1, 1949·The Journal of Clinical Endocrinology and Metabolism·W BICKERS
Apr 1, 1947·The Journal of Clinical Endocrinology and Metabolism·R S FINKLER


Apr 25, 1986·Biochimica Et Biophysica Acta·M S Ardawi, E A Newsholme
Dec 28, 1989·Biochimica Et Biophysica Acta·B H StewartH N Christensen
Aug 1, 1982·Biochemical Pharmacology·N Y Liang, C O Rutledge
Jul 1, 1983·Chemico-biological Interactions·J K MalikF J Wiebel
Oct 1, 1978·Chemistry and Physics of Lipids·G P MartinC Marriott
Jan 15, 1980·Clinica Chimica Acta; International Journal of Clinical Chemistry·L Hagenfeldt, A Arvidsson
Nov 1, 1978·Developmental Biology·C MlotA E Hampel
Dec 1, 1980·Developmental Biology·C MilotA E Hampel
Nov 1, 1990·Developmental Biology·L J Van WinkleR L Garton
Nov 7, 1983·Life Sciences·H H TallanG E Gaull
May 1, 1976·Mechanisms of Ageing and Development·S GoldsteinR A Cordeiro
Jan 1, 1986·Pharmacology, Biochemistry, and Behavior·S SamuelsS A Schwartz
Jan 1, 1984·Comparative Biochemistry and Physiology. A, Comparative Physiology·J Lerner
Jan 1, 1986·Comparative Biochemistry and Physiology. A, Comparative Physiology·A PonsM Alemany
Nov 14, 1977·Biochimica Et Biophysica Acta·S Schuldiner, H R Kaback
May 31, 1977·Biochimica Et Biophysica Acta·A E Shamoo, D A Goldstein
May 24, 1983·Biochimica Et Biophysica Acta·M A ShotwellD L Oxender
Sep 9, 1985·Biochimica Et Biophysica Acta·D L Yudilevich, J H Sweiry
Oct 11, 1988·Biochimica Et Biophysica Acta·S Forster, J B Lloyd
Dec 12, 1991·Biochimica Et Biophysica Acta·R L Pisoni, J G Thoene
Jun 1, 2005·Journal of Controlled Release : Official Journal of the Controlled Release Society·Joseph A NicolazzoBarrie C Finnin
Jun 1, 1977·British Journal of Clinical Pharmacology·M E PickupM P Harrison
Oct 1, 1977·British Journal of Clinical Pharmacology·W Schürmann, P Turner
Oct 1, 1979·British Journal of Clinical Pharmacology·C G SwiftI H Stevenson
Feb 1, 1979·The Journal of Pharmacy and Pharmacology·S A Sprake, D F Evered
Sep 1, 2012·AAPS PharmSciTech·Jeremy A Bartlett, Kees van der Voort Maarschalk
Aug 1, 1976·Journal of Pharmaceutical Sciences·F W Goodhart, M L Eichman
Jul 6, 2004·Journal of Pharmaceutical Sciences·Joseph A NicolazzoBarrie C Finnin
Nov 1, 1990·Journal of Pharmaceutical Sciences·H YamaharaM Samejima
Jul 13, 2002·Journal of Pharmaceutical Sciences·Ashwinkumar C JainMoji Christianah Adeyeye
Feb 1, 1982·The Journal of Dermatology·H Osamura
Jul 1, 1980·British Journal of Clinical Pharmacology·J A HenryP Turner
Jun 1, 2014·International Journal of Pharmaceutics·Mohammed SattarMajella E Lane
Nov 1, 1992·Journal of Dental Research·M L WeaverP A Kramer
Nov 1, 1977·The Journal of Pharmacy and Pharmacology·M E Pickup, A H Beckett
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·G P MartinC Marriott
Dec 1, 1977·The Journal of Pharmacy and Pharmacology·O P HoB J Meakin

Related Concepts

Process of Absorption
Chromatography, Gas-Liquid
Computers, Analog
Tissue Membrane
Buccal Mucosa
Catatoxic Steroids

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