A model for the management of an atypical endophthalmitis outbreak

Eye
O A AndersonG Vafidis

Abstract

To present a model for the assessment, investigation, and management of an atypical outbreak of infectious endophthalmitis of indeterminate aetiology. A published statistical model was used to determine when the case-load constituted an outbreak. Intraocular surgery was discontinued and a multidisciplinary infection control team was formed aimed at identifying potential causative factors among the following categories: environment around theatre, preoperative preparation, intraoperative theatre practices, intraoperative surgical practices, postoperative practices, equipment maintenance guidelines, cleaning/sterilization practices, and microbiological screening. Five cases of postoperative endophthalmitis developed following uncomplicated phacoemulsification cataract surgery by different surgeons over a 7-month period. Despite full investigation no single focus of infection could be determined. Four out of five cases were culture positive. Three grew Streptococcus viridans of different strains. The fourth culture grew Staphylococcus aureus. In the absence of a single causative factor, it was postulated the combined effect of multiple potential factors may have led to an increased bacterial load and subsequent infection rate. Imp...Continue Reading

References

Dec 1, 1991·Ophthalmology·J A MenikoffE M Raskin
Dec 1, 1991·Ophthalmology·M G Speaker, J A Menikoff
Apr 1, 1995·The British Journal of Ophthalmology·A DoyleR Hone
Oct 1, 1994·Acta Ophthalmologica·D L DereklisS I Palassopoulos
Mar 1, 1994·Ophthalmology·W B Phillips, W S Tasman
Feb 1, 1996·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·S K FridkinW R Jarvis
Jul 1, 1997·Journal of Cataract and Refractive Surgery·O J LehmannJ I McGill
Nov 5, 1998·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·E I AssiaN Keller
Jan 30, 1999·The British Journal of Ophthalmology·J W BainbridgeC K Rostron
Oct 16, 1999·Ophthalmology·S SchmitzN Pfeiffer
Nov 27, 1999·The British Journal of Ophthalmology·P DesaiA Reidy
Jan 5, 2002·Ophthalmology·Thomas A CiullaSamuel Masket
Apr 30, 2002·Journal of Cataract and Refractive Surgery·James K LeongR Frank Taylor
May 1, 2002·Graefe's Archive for Clinical and Experimental Ophthalmology = Albrecht Von Graefes Archiv Für Klinische Und Experimentelle Ophthalmologie·P JanknechtT Ness
May 29, 2002·Eye·S Dinakaran, V V Kayarkar
May 31, 2002·Journal of Cataract and Refractive Surgery·Per G MontanMargareta Rylander
May 31, 2002·Journal of Cataract and Refractive Surgery·Per G MontanCharlotta Zetterström
Aug 20, 2002·The British Journal of Ophthalmology·A AlwitryR Holden
Sep 17, 2002·Journal of Cataract and Refractive Surgery·Andrew C BrowningWinfried M Amoaku
Dec 25, 2002·Journal of Cataract and Refractive Surgery·Renuka SrinivasanMangudi Kanakasabai Natarajan
Jan 29, 2003·Journal of Cataract and Refractive Surgery·Yasunori NagakiTomohiro Abe
Jul 31, 2003·American Journal of Ophthalmology·Blake A CooperPaul A Thompson

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Citations

Aug 26, 2014·Jundishapur Journal of Microbiology·Bibi Sedigheh Fazly BazzazBahman Khameneh
Nov 13, 2007·Ophthalmology·Jonathon Q NgJames B Semmens
Mar 21, 2007·Emerging Infectious Diseases·Vanaporn WuthiekanunSharon J Peacock
Sep 8, 2011·The American Journal of Tropical Medicine and Hygiene·Elizabeth F DaherAlexandre B Libório
Jul 11, 2013·International Journal of Experimental Pathology·Karen McCreesh, Jeremy Lewis

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