A model for transgenerational imprinting variation in complex traits.

PloS One
Chenguang WangRongling Wu

Abstract

Despite the fact that genetic imprinting, i.e., differential expression of the same allele due to its different parental origins, plays a pivotal role in controlling complex traits or diseases, the origin, action and transmission mode of imprinted genes have still remained largely unexplored. We present a new strategy for studying these properties of genetic imprinting with a two-stage reciprocal F mating design, initiated with two contrasting inbred lines. This strategy maps quantitative trait loci that are imprinted (i.e., iQTLs) based on their segregation and transmission across different generations. By incorporating the allelic configuration of an iQTL genotype into a mixture model framework, this strategy provides a path to trace the parental origin of alleles from previous generations. The imprinting effects of iQTLs and their interactions with other traditionally defined genetic effects, expressed in different generations, are estimated and tested by implementing the EM algorithm. The strategy was used to map iQTLs responsible for survival time with four reciprocal F populations and test whether and how the detected iQTLs inherit their imprinting effects into the next generation. The new strategy will provide a tool for...Continue Reading

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Citations

Dec 29, 2012·Briefings in Bioinformatics·Yanru ZengRongling Wu
Jan 22, 2013·Briefings in Bioinformatics·Yihan SuiRongling Wu
Aug 30, 2012·Briefings in Bioinformatics·Zhong WangRongling Wu
Jul 28, 2013·Briefings in Bioinformatics·Xin LiRongling Wu
May 14, 2011·Briefings in Bioinformatics·Chenguang WangRongling Wu
Oct 30, 2012·BMC Bioinformatics·Zhong WangRongling Wu
Jun 23, 2012·Briefings in Bioinformatics·Xiaoming PangRongling Wu
Jun 22, 2015·Trends in Plant Science·Lidan SunRongling Wu
Mar 17, 2015·Physics of Life Reviews·Lidan Sun, Rongling Wu
Jun 15, 2014·Briefings in Bioinformatics·Lidan SunRongling Wu
Apr 23, 2019·The Plant Journal : for Cell and Molecular Biology·Yanru ZengRongling Wu

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