PMID: 8388778Mar 1, 1993

A model of calcium regulation in smooth muscle cell

Cell Calcium
A Y Wong, G A Klassen

Abstract

A model of smooth muscle cell is proposed to describe the mechanisms by which intracellular calcium (Cai) is regulated when the cell is stimulated by noradrenaline (NA)/agonist (Ag) or depolarized. The intracellular Ca2+ store is comprised of two calcium pools: A-store which is sensitive to inositol 1,4,5 trisphosphate (IP3) and C-store, insensitive to IP3 but sensitive to Cai. The A-store is refilled by Ca2+ from C-store and reuptake of Cai. The uptake rate is dependent on the degree of filling in the A-store. The C-store, activated by Cai, is replenished by extracellular Ca2+ (Cao). IP3 generated by NA or Ag changes the A-store permeability, discharging its Ca2+ into the cytosol. Depolarization activates Ca2+ current through the L-type channels. The following events are simulated and compared with experimental observations: (a) Cai transient stimulated by high K+; (b) Cai transient and Ca2+ efflux induced by shortlasting and longlasting NA in the absence of Cao; (c) effect of lanthanum on NA-induced Cai and Ca2+ efflux; and (d) effects of nifedipine, ryanodine, BAY K 8644 and cyclopiazonic acid on Cai.

References

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Citations

Nov 11, 1990·Cell Calcium·J W Putney
Feb 1, 1987·Pflügers Archiv : European journal of physiology·K NakazawaY Kasuya
Feb 1, 1987·Pflügers Archiv : European journal of physiology·J V Walsh, J J Singer
Aug 1, 1989·The Journal of General Physiology·M Iino
Apr 15, 1988·Biochemical and Biophysical Research Communications·M IinoM Endo
Jul 15, 1985·Experientia·A V Somlyo, C Franzini-Armstrong
Mar 1, 1972·The Journal of Cell Biology·C E DevineA V Somlyo
Aug 1, 1982·The Journal of General Physiology·K Saida
Jan 1, 1992·Bulletin of Mathematical Biology·A Y WongJ B Bassingthwaighthe

Related Concepts

Muscle, Smooth, Vascular
Calcium
Calcium Channel
Theoretical Study
Norepinephrine, (+, -)-Isomer
Ryanodine
Inotropism
Lanthanum
Inositol 1,4,5-Trisphosphate
Cytoplasmic Matrix

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