PMID: 6159103Nov 1, 1980Paper

A model of cell activation and desensitization by surface immunoglobin: the case of histamine release from human basophils

Cell
M Dembo, B Goldstein

Abstract

We present a model for the control of immunoglobulin E (IgE)-mediated histamine release from human basophils. We suggest that there is a calcium gating factor which interacts with crosslinked IgE to form a short-lived open calcium channel. After formation of the channel the activated gating factor rapidly decays to an inactive form. It is the loss of the active gating factor which causes the basophil to desensitize nonspecifically. We propose that the crosslinked IgE molecules are deactivated by a mechanism, such as endocytosis or shedding, which is independent of the mechanism which inactivates the calcium gating factor. This loss of functional IgE leads to specific desensitization. The mathematical formulation of the model explains the relationship of specific and nonspecific desensitization to the amount of specific IgE on the basophil surface; explains why there are two types of antigen excess inhibition; explains the relationship between antigen excess inhibition and desensitization; explains why, for a fixed antigen concentration, increasing the concentration of cell surface IgE increases histamine release until an optimal concentration is reached, then decreases histamine release; predicts the effects that changing the e...Continue Reading

References

Jan 1, 1975·Transplantation Reviews·G I Bell
Jul 1, 1977·Proceedings of the National Academy of Sciences of the United States of America·D M SegalH Metzger
Sep 1, 1978·Proceedings of the National Academy of Sciences of the United States of America·C R KahnJ S Flier
Aug 1, 1970·Immunochemistry·K IshizakaE H Lee
Aug 1, 1973·The Journal of Experimental Medicine·K E BeckerP M Grimley
Dec 1, 1974·The Journal of Experimental Medicine·A Kulczycki, H Metzger
Nov 1, 1968·British Journal of Pharmacology·W W Douglas
Apr 1, 1980·Proceedings of the National Academy of Sciences of the United States of America·T IshizakaJ Axelrod

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Citations

Jul 1, 1991·Journal of Cellular Physiology·J SeagraveJ M Oliver
Jan 1, 1993·The Journal of Allergy and Clinical Immunology·R ValentaD Kraft
Mar 1, 1982·Molecular Immunology·M DemboB Goldstein
Oct 6, 1998·Journal of Immunological Methods·S J Merrill
Nov 16, 2010·IET Systems Biology·Ambarish NagByron Goldstein
Aug 13, 1998·Immunological Reviews·Z Weng, C DeLisi
Mar 9, 1994·Annals of the New York Academy of Sciences·B D GompertsP E Tatham
Jan 1, 1990·Critical Reviews in Oncology/hematology·P Valent, P Bettelheim
May 8, 1999·Biophysical Journal·W S HlavacekR G Posner
Jan 1, 2017·The Journal of Immunology : Official Journal of the American Association of Immunologists·Avanika MahajanBridget S Wilson
Mar 21, 1998·The Journal of School Health·L DusenburyK Bosworth
May 14, 2009·Journal of Leukocyte Biology·Susan Ishmael, Donald MacGlashan
May 8, 2003·The Journal of Immunology : Official Journal of the American Association of Immunologists·Donald MacGlashan
Mar 7, 2019·Royal Society Open Science·Md ShahinuzzamanDipak Barua
Sep 2, 1998·The Journal of Allergy and Clinical Immunology·C L KepleyJ M Oliver

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