PMID: 3752641Jan 1, 1986Paper

A model of deposition and embolization of proteins and platelets on biomaterial surfaces

Annals of Biomedical Engineering
R S WilsonS L Cooper

Abstract

A theoretical model for the deposition and detachment of protein and platelets on biomaterial surfaces is presented here. This work is an extension of the model previously reported. Two mechanisms of protein and platelet removal are assumed: A characteristic time elapses before adsorbed protein detaches from the surface, carrying away platelets and protein which have deposited on top of it; and thrombi that attain a critical size are subject to hydrodynamic forces which embolize them from the surface. A theoretical distribution of thrombus sizes is assumed. Analysis of the effects of varying model parameters on predicted protein and platelet deposition reveals that the addition of the embolization process does not change the overall structure of the deposition profiles, but does significantly affect the finer details.

References

Jan 1, 1977·Proceedings of the British Paedodontic Society·P J CrawfordJ Grogan
Jan 1, 1979·Thrombosis Research·J V IhlenfeldS L Cooper
May 7, 1977·Journal of Theoretical Biology·E RuckensteinW N Gill
May 1, 1984·Journal of Biomedical Materials Research·M D LelahS L Cooper
Jan 1, 1982·Annals of Biomedical Engineering·A B StrongB E Thompson

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Citations

Jan 1, 1991·Journal of Biomaterials Science. Polymer Edition·J van Straaten, N A Peppas
Jan 1, 1993·Journal of Biomaterials Science. Polymer Edition·L O ReynoldsI F Miller
Sep 25, 2014·International Journal for Numerical Methods in Biomedical Engineering·F Storti, F N van de Vosse
Jul 10, 2003·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Radoslaw KowalewskiJerzy Glowinski
May 24, 2015·Optometry and Vision Science : Official Publication of the American Academy of Optometry·Negar Babaei OmaliLyndon W Jones
Nov 1, 1989·Journal of Biomedical Materials Research·D Basmadjian

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