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A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

Biochimie

Jun 6, 2012

Steven WattersonPeter Ghazal

Abstract

The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalysing each metabolic step. In contrast, statin based drugs, whi...read more

Mentioned in this Paper

Dengue Fever
Metabolic Process, Cellular
Real-Time Polymerase Chain Reaction
Immune Response
Biochemical Pathway
Epicholesterol
zymosterol
Transcriptional Regulation
Prenylation
Virus Diseases
2
1
44
Paper Details
References
  • References31
  • Citations9
1234
  • References31
  • Citations9
1

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A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

Biochimie

Jun 6, 2012

Steven WattersonPeter Ghazal

PMID: 22664637

DOI: 10.1016/j.biochi.2012.05.024

Abstract

The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalysing each metabolic step. In contrast, statin based drugs, whi...read more

Mentioned in this Paper

Dengue Fever
Metabolic Process, Cellular
Real-Time Polymerase Chain Reaction
Immune Response
Biochemical Pathway
Epicholesterol
zymosterol
Transcriptional Regulation
Prenylation
Virus Diseases
2
1
44

Similar Papers Found In These Feeds

Hepatitis C

Hepatitis C virus causes acute and chronic liver disease in humans, including chronic hepatitis, cirrhosis, and hepatocellular carcinoma. Discover the latest research on Hepatitis C here.

Lipid Metabolism

Lipid metabolism is important in several cellular processes and functions including signal transduction. Disorders of lipid metabolism can occur impairing normal function. Here is the latest research on lipid metabolism and lipid disorders.

Related Papers

EURASIP Journal on Bioinformatics & Systems Biology

A systems biology approach to analyse leaf carbohydrate metabolism in Arabidopsis thaliana

EURASIP Journal on Bioinformatics & Systems BiologySeptember 14, 2011
Sebastian HenkelArnd G Heyer
Paper Details
References
  • References31
  • Citations9
1234
  • References31
  • Citations9
1
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