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A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

bioRxiv

Nov 14, 2013

Steven WattersonPeter Ghazal

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Abstract

The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalyzing each metabolic step. In contrast, statin based drugs, whi...read more

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Enzymes, antithrombotic
Enzymes, peripheral vasodilators
Enzymes, hematological
Biochemical Pathway
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Down-Regulation
Cholesterol Measurement Test
Virus Diseases
Metabolite
Metabolic Process, Cellular
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  • A model of flux regulation in the cholesterol biosynthesis pathway: Immune mediated graduated flux reduction versus statin-like led stepped flux reduction

    bioRxiv

    Nov 14, 2013

    Steven WattersonPeter Ghazal

    PMID: 990000380

    DOI: 10.1101/000380

    Abstract

    The cholesterol biosynthesis pathway has recently been shown to play an important role in the innate immune response to viral infection with host protection occurring through a coordinate down regulation of the enzymes catalyzing each metabolic step. In contrast, statin based drugs, whi...read more

    Mentioned in this Paper

    Enzymes, antithrombotic
    Enzymes, peripheral vasodilators
    Enzymes, hematological
    Biochemical Pathway
    Hydroxymethylglutaryl-CoA Reductase Inhibitors
    Paper Details
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      We're still populating references for this paper, please check back later.
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