PMID: 1195349Jan 1, 1975Paper

A model of NaCl and water flow through paracellular pathways of renal proximal tubules

The Journal of Membrane Biology
R E Huss, D J Marsh

Abstract

To explain how hydrostatic pressure differences between tubule lumen and interstitium modulate isotonic reabsorption rates, we developed a model of NaCl and water flow through paracellular pathways of the proximal tubule. Structural elements of the model are a tight junction membrane, an intercellular channel whose walls transport NaCl actively at a constant rate, and a basement membrane. Equations of change were derived for the channel, boundary conditions were formulated from irreversible thermodynamics, and a pressure-area relationship typical of thin-walled tubing was assumed. The boundary value problem was solved numerically. The principal conclusions are: 1) channel NaCl concentration must remain within a few mOsm of isotonic values for reabsorption rates to be modulated by transtubular pressure differences known to affect this system: 2) basement membrane and channel wall parameters determine reabsorbate tonicity; tight junction parameters affect the sensitivity of reabsorption to transmural pressure; 3) channel NaCl concentration varies inversely with transmural pressure difference; this concentration variation controls NaCl diffusion through the tight junction; 4) modulation of NaCl diffusion through the tight junction...Continue Reading

References

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Citations

Jan 1, 1981·Cell and Tissue Research·A Schiller, K Tiedemann
Dec 1, 1979·Pflügers Archiv : European journal of physiology·H AlbusJ Siegenbeek van Heukelom
Dec 31, 1979·The Journal of Membrane Biology·J M Diamond
Jun 7, 1979·The Journal of Membrane Biology·R E Huss, J L Stephenson
May 15, 1981·The Journal of Membrane Biology·A M Weinstein, J L Stephenson
Aug 1, 1979·Biophysical Journal·A M Weinstein, J L Stephenson
May 1, 1985·The Journal of General Physiology·S McLaughlin, R T Mathias
Jan 1, 1981·The Journal of Membrane Biology·J Siegenbeek van HeukelomJ A Groot
Oct 1, 1982·Pflügers Archiv : European journal of physiology·J Siegenbeek van HeukelomK Dekker
Apr 5, 2003·American Journal of Physiology. Renal Physiology·Alan M Weinstein
Mar 16, 2019·Scientific Reports·Oleksandr OstrenkoLutz Brusch

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