A model of transient myocardial dysfunction in conscious dogs. Regional shortening in the presence of impaired coronary flow reserve and treadmill exercise

Journal of Pharmacological Methods
G RabergerN Mayer

Abstract

An experimental model of treadmill exercise-induced regional myocardial dysfunction was developed in conscious dogs to mimic exertional angina pectoris in man. Twenty mongrel dogs, trained to run on a treadmill, were chronically instrumented with a miniature pressure transducer in the left ventricle and a hydraulic occluder placed around the circumflex branch of the left coronary artery. Two pairs of piezoelectric crystals for sonomicrometry were implanted subendocardially to measure regional myocardial function. Experiments were started 1 week after surgery. In the first group of ten dogs exercise with constant work load of 10 km/hr and 10% elevation during partial left coronary artery stenosis, induced by external filling of the occluder, produced comparable episodes of regional dysfunction in the left coronary artery area during five subsequent treadmill runs and recovery of function after each run. The second group of ten dogs, exercised with left coronary artery stenosis and increasing working load, exhibited minimal regional dysfunction in the left coronary artery area while running at 6 km/hr and 6% elevation, but maximal regional dysfunction during peak exercise (10 km/hr and 10% elevation). This load dependency and rec...Continue Reading

References

Jan 1, 1975·The American Journal of Cardiology·W A NeillR P Anderson
May 1, 1985·Journal of Cardiovascular Pharmacology·P FitschaG Raberger
Jul 1, 1986·International Journal of Cardiology·G KrumplG Raberger
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Citations

Jan 1, 1990·Research in Experimental Medicine. Zeitschrift Für Die Gesamte Experimentelle Medizin Einschliesslich Experimenteller Chirurgie·W SchneiderG Raberger
Dec 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·G KrumplG Raberger
Oct 14, 1986·European Journal of Pharmacology·G KrumplG Raberger
Jul 1, 1986·International Journal of Cardiology·G KrumplG Raberger
Nov 1, 1986·Clinical and Experimental Pharmacology & Physiology·N MayerG Raberger
Aug 1, 1990·British Journal of Pharmacology·G KrumplG Raberger
Mar 1, 1987·International Journal of Cardiology·G RabergerW Schneider

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