A model of ventilation of the healthy human lung

Computer Methods and Programs in Biomedicine
K S SteimleS Andreassen

Abstract

This paper presents a model of the lung mechanics which simulates the pulmonary alveolar ventilation. The model includes aspects of: the alveolar geometry; pressure due to the chest wall; pressure due to surface tension determined by surfactant activity; pressure due to lung tissue elasticity; and pressure due to the hydrostatic effects of the lung tissue and blood. The cross-sectional area of the lungs in the supine position derived from computed tomography is used to construct a horizontally layered model, which simulates heterogeneous ventilation distribution from the non-dependent to the dependent layers of the lungs. The model is in agreement with experimentally measured hysteresis of the pressure-volume curve of the lungs, static lung compliance, changes in lung depth during breathing and density distributions at total lung capacity (TLC) and residual volume (RV). In the dependent layers of the lungs, alveolar collapse may occur at RV, depending on the assumptions concerning lung tissue elasticity at very low alveolar volumes. The model simulations showed that ventilation increased with depth in the lungs, although not as pronounced as observed experimentally. The model simulates alveolar ventilation including all of the ...Continue Reading

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Citations

Aug 21, 2010·Journal of Applied Physiology·Steen AndreassenDan S Karbing
Jan 26, 2012·Drug Safety : an International Journal of Medical Toxicology and Drug Experience·Silas W SmithJeffrey K Aronson
Aug 13, 2015·Intensive Care Medicine Experimental·Wenfei WangDeclan G Bates
Jul 30, 2010·Computer Methods and Programs in Biomedicine·M L MogensenS Andreassen
Sep 14, 2015·Computer Methods and Programs in Biomedicine·Jarosław GlapińskiAdam G Polak
Oct 31, 2018·Scandinavian Journal of Medicine & Science in Sports·Jochen D SchipkeFlorian Boenner
Sep 18, 2013·The Open Biomedical Engineering Journal·Paolo BarbiniGianni Gnudi
Nov 14, 2018·Biomedical Engineering Online·Vincent J MajorJ Geoffrey Chase
Dec 12, 2020·Frontiers in Cell and Developmental Biology·Juho LiekkinenMatti Javanainen
Dec 29, 2020·Computer Methods and Programs in Biomedicine·Cong ZhouThomas Desaive
Feb 21, 2019·Respiration; International Review of Thoracic Diseases·Jochen D SchipkeKay Tetzlaff

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