A model-specific role of microRNA-223 as a mediator of kidney injury during experimental sepsis.

American Journal of Physiology. Renal Physiology
James F ColbertAdit A Ginde

Abstract

Sepsis outcomes are heavily dependent on the development of septic organ injury, but no interventions exist to interrupt or reverse this process. microRNA-223 (miR-223) is known to be involved in both inflammatory gene regulation and host-pathogen interactions key to the pathogenesis of sepsis. The goal of this study was to determine the role of miR-223 as a mediator of septic kidney injury. Using miR-223 knockout mice and multiple models of experimental sepsis, we found that miR-223 differentially influences acute kidney injury (AKI) based on the model used. In the absence of miR-223, mice demonstrated exaggerated AKI in sterile models of sepsis (LPS injection) and attenuated AKI in a live-infection model of sepsis (cecal ligation and puncture). We demonstrated that miR-223 expression is induced in kidney homogenate after cecal ligation and puncture, but not after LPS or fecal slurry injection. We investigated additional potential mechanistic explanations including differences in peritoneal bacterial clearance and host stool virulence. Our findings highlight the complex role of miR-223 in the pathogenesis of septic kidney injury, as well as the importance of differences in experimental sepsis models and their consequent transl...Continue Reading

References

Apr 18, 2003·The New England Journal of Medicine·Greg S MartinMarc Moss
Dec 24, 2005·Shock·William J HubbardIrshad H Chaudry
Nov 3, 2007·BMJ : British Medical Journal·Iain Mackenzie, Andrew Lever
Dec 11, 2007·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Michael OppertUNKNOWN German Competence Network Sepsis (Sepnet)
Feb 19, 2008·Nature·Jonathan B JohnnidisFernando D Camargo
Mar 8, 2008·Critical Care : the Official Journal of the Critical Care Forum·Christoph LangenbergRinaldo Bellomo
Feb 8, 2011·Trends in Microbiology·Lien DejagerClaude Libert
Jul 8, 2011·Clinical Journal of the American Society of Nephrology : CJASN·Maria PlatakiRodrigo Cartin-Ceba
Dec 22, 2011·JAMA : the Journal of the American Medical Association·Derek C Angus
Apr 24, 2012·American Journal of Physiology. Lung Cellular and Molecular Physiology·Bernard J FisherRamesh Natarajan
Jun 30, 2012·The Lancet Infectious Diseases·Jonathan CohenThierry Calandra
Jan 26, 2013·American Journal of Respiratory and Critical Care Medicine·Osamu TakasuRichard S Hotchkiss
Dec 10, 2013·Nature·Michelle G RoyChristopher M Evans
Jan 9, 2014·Physiological Reports·Melissa I LygizosEric P Schmidt
Aug 3, 2014·Biochimica Et Biophysica Acta·Kobina Essandoh, Guo-Chang Fan
Feb 24, 2016·JAMA : the Journal of the American Medical Association·Mervyn SingerDerek C Angus
Jul 20, 2016·Current Infectious Disease Reports·S Manoj Kumar Kingsley, B Vishnu Bhat

❮ Previous
Next ❯

Citations

Apr 11, 2019·American Journal of Physiology. Cell Physiology·Zhiwen LiuZheng Dong
Dec 22, 2017·Experimental Biology and Medicine·Yan-Fang Zou, Wen Zhang
Aug 10, 2019·Anesthesia and Analgesia·Ettore CrimiClaudio Napoli
Nov 7, 2019·Anesthesiology·Sam D GumbertHolger K Eltzschig
Apr 9, 2020·American Journal of Physiology. Lung Cellular and Molecular Physiology·Chunlin YeJian Tang
May 26, 2018·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Valérie Metzinger-Le MeuthLaurent Metzinger
Jul 31, 2020·International Journal of Molecular Sciences·Pál TodPéter Hamar
Apr 17, 2020·International Journal of Environmental Research and Public Health·Honglin QuRui Chen
Jul 10, 2019·Journal of the American Society of Nephrology : JASN·Sonia ZambranoJaakko Patrakka
Dec 29, 2020·American Journal of Physiology. Renal Physiology·Mengxi ZhangXinling Liang

❮ Previous
Next ❯

Methods Mentioned

BETA
BioAssay
lavage

Software Mentioned

GraphPad Prism

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.