PMID: 2502775Feb 1, 1989Paper

A model system for studying the bioavailability of intestinally administered microcystin-LR, a hepatotoxic peptide from the cyanobacterium Microcystis aeruginosa

Pharmacology & Toxicology
A M DahlemV R Beasley

Abstract

Sprague-Dawley rats were used to evaluate a model system for studying the hepatotoxicity caused by microcystin-LR (MCYST-LR), a toxin produced by the cyanobacterium (blue-green alga) Microcystis aeruginosa, and for evaluating the in vivo therapeutic potential of cholestyramine resin (CTR) which was found to bind the toxin in vitro. Female rats were treated with either toxin or an equivalent volume of the saline vehicle by direct administration into the lumen of an in situ isolated ileal loop. Male rats were dosed with toxin as described above, and then animals were dosed in the ileal loop with either cholestyramine resin (CTR, 50 mg/rat) or an equivalent vehicle. The survivors in both studies were killed six hours after dosing and hepatotoxicity was assessed by change in relative liver weights. In all groups given toxin alone, there was a significant increase in liver weight and males and females were equally susceptible. Liver weights of the toxin plus CTR treated rats were similar to those in vehicle-treated rats. When the toxin was administered into a similarly isolated jejunal loop, liver weight was significantly less than that found when an equivalent dose was administered into the ileal loop suggesting an intestinal site ...Continue Reading

References

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Citations

Jun 5, 2003·Comparative Biochemistry and Physiology. Toxicology & Pharmacology : CBP·Christelle MalbrouckPatrick Kestemont
Mar 15, 2005·Journal of Toxicology and Environmental Health. Part B, Critical Reviews·Ronald W ZurawellEllie E Prepas
Jun 13, 2001·Environmental Health Perspectives·R C Shoemaker, H K Hudnell
Feb 1, 1991·Journal of Applied Toxicology : JAT·S J HermanskyK A Mereish
Apr 21, 2009·Toxicon : Official Journal of the International Society on Toxinology·Paweł BrzuzanStefan Dobosz
Oct 3, 2006·Neurotoxicology and Teratology·Ritchie C Shoemaker, Dennis E House
May 7, 2016·Veterinary Sciences·Lorraine C Backer, Melissa Miller
Mar 1, 1990·The Veterinary Clinics of North America. Small Animal Practice·V R Beasley, D C Dorman
Mar 13, 2014·Chemistry : a European Journal·Andrés Feher-VoelgerTomás Martín
Nov 16, 2018·Journal of Toxicology and Environmental Health. Part a·Cong WenFei Yang
Apr 21, 2016·Veterinary Sciences·Lorraine C Backer, Melissa Miller
Dec 14, 2004·Revista Da Sociedade Brasileira De Medicina Tropical·Andréa de Castro Leal, Manoel do Carmo Pereira Soares
Oct 5, 2018·World Journal of Clinical Cases·Jin-Xia WuHui-Zhen Zhang
Jun 29, 2012·Journal of the American Chemical Society·Johannes G BeckHorst Kessler

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