A model that integrates eye velocity commands to keep track of smooth eye displacements.

Journal of Computational Neuroscience
G BlohmP Lefèvre

Abstract

Past results have reported conflicting findings on the oculomotor system's ability to keep track of smooth eye movements in darkness. Whereas some results indicate that saccades cannot compensate for smooth eye displacements, others report that memory-guided saccades during smooth pursuit are spatially correct. Recently, it was shown that the amount of time before the saccade made a difference: short-latency saccades were retinotopically coded, whereas long-latency saccades were spatially coded. Here, we propose a model of the saccadic system that can explain the available experimental data. The novel part of this model consists of a delayed integration of efferent smooth eye velocity commands. Two alternative physiologically realistic neural mechanisms for this integration stage are proposed. Model simulations accurately reproduced prior findings. Thus, this model reconciles the earlier contradictory reports from the literature about compensation for smooth eye movements before saccades because it involves a slow integration process.

References

Jan 1, 1979·Vision Research·W Becker, R Jürgens
Sep 19, 1975·Science·F A Miles, J H Fuller
Jan 1, 1976·Vision Research·P E Hallett, A D Lightstone
Jan 1, 1976·Vision Research·P E Hallett, A D Lightstone
Dec 1, 1992·Current Opinion in Neurobiology·R A AndersenP Mazzoni
Jan 1, 1992·Experimental Brain Research·P DassonvilleM Schlag-Rey
Jan 1, 1992·Experimental Brain Research·R S Gellman, W A Fletcher
Oct 1, 1990·Trends in Neurosciences·J Schlag, M Schlag-Rey
Sep 1, 1991·Journal of Neurophysiology·S BarashR A Andersen
Jan 1, 1991·Experimental Brain Research·R S Gellman, J R Carl
Nov 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·J Droulez, A Berthoz
Jan 1, 1991·Experimental Brain Research·C Pierrot-DeseillignyY Agid
Aug 1, 1990·Journal of Neurophysiology·J SchlagP Dassonville
Jan 1, 1990·Experimental Brain Research·E Keller, S D Johnsen
Feb 1, 1988·Annals of Neurology·R J Tusa, L G Ungerleider
Jan 1, 1987·Vision Research·R N Aslin, S L Shea
Jun 8, 1986·The Journal of Comparative Neurology·L G Ungerleider, R Desimone
Nov 1, 1985·Journal of Neurophysiology·W F Crandall, E L Keller
Dec 31, 1973·Kybernetik·D A Robinson
May 1, 1970·Journal of Neurophysiology·D A Robinson
Sep 1, 1984·Journal of Neurophysiology·D J Felleman, J H Kaas
Jun 6, 1980·Science·L E Mays, D L Sparks
Jan 1, 1983·Journal of Neurophysiology·E L Keller, W F Crandall
Mar 1, 1981·Journal of Neurophysiology·J A Van GisbergenS Gielen

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Citations

Sep 3, 2010·The Journal of Neuroscience : the Official Journal of the Society for Neuroscience·Vincent P Ferrera, Andrei Barborica
Apr 5, 2011·Annual Review of Neuroscience·J Douglas CrawfordW Pieter Medendorp
Aug 11, 2007·The Journal of Physiology·Jean-Jacques Orban de Xivry, Philippe Lefèvre
Sep 13, 2008·Neuroscience·E M Klier, D E Angelaki
Sep 26, 2013·Cerebral Cortex·Kalpana DokkaDora E Angelaki
Jun 1, 2016·Frontiers in Systems Neuroscience·Yalda MohsenzadehJ Douglas Crawford
Dec 29, 2020·Journal of Neurophysiology·Jonathan D CoutinhoGunnar Blohm

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