A model to detect interactions between roxithromycin and oral contraceptives

Clinical Pharmacology and Therapeutics
B MeyerJ Maree

Abstract

Twenty-two healthy women participated in a study to determine whether roxithromycin (a new macrolide antibiotic agent) obtunds the activity of a triphasic oral contraceptive. The duration of the study was four menstrual cycles. Medication was given as follows: (1) cycle 1, no medication to demonstrate ovulation; (2) cycle 2, triphasic oral contraceptive daily to suppress ovulation; (3) cycle 3, triphasic oral contraceptive daily plus roxithromycin, 150 mg b.i.d.; and (4) cycle 4, triphasic oral contraceptive daily plus rifampin, 300 mg daily. Sonography of the ovaries was performed on day 13, and serum progesterone was measured on day 21 of each cycle. Elevated progesterone indicated ovulation. The presence of a maturing follicle supported this finding. All volunteers ovulated in the first cycle and no volunteers ovulated in the second and third cycles. However, 11 women ovulated when rifampin and the triphasic oral contraceptive were given concomitantly. The findings suggest there is no reason to believe that roxithromycin interferes with the efficacy of oral contraceptives.

Citations

Jun 1, 1999·Journal of Clinical Psychopharmacology·J W McAuley, C I Friedman
Nov 14, 2017·BJOG : an International Journal of Obstetrics and Gynaecology·K B SimmonsK M Curtis
Jun 1, 2005·The Journal of Family Planning and Reproductive Health Care·UNKNOWN Faculty of Family Planning and Reproductive Health Care Clinical Effectiveness Unit
Mar 6, 2018·Basic & Clinical Pharmacology & Toxicology·Anton PottegårdPer Damkier
Jun 14, 2002·Journal of the American Academy of Dermatology·Johanna S M Archer, David F Archer
Feb 26, 1999·The Journal of the American Dental Association·E V Hersh

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