A model to estimate the dose to tumour following intracavity administration of radioimmunoconjugates to patients with malignant gliomas

The British Journal of Radiology
K HopkinsJ T Kemshead

Abstract

Patients who have relapsed following primary treatment for malignant glioma and have undergone further surgical debulking have been treated with an anti-human neural cell adhesion molecule (NCAM) MoAb linked to either Iodine-131 or Yttrium-90. These reagents are introduced into the tumour resection cavity via an Ommaya reservoir. Pharmacokinetic and imaging studies indicate that the radioimmunoconjugate remains within the cavity for a protracted period of time. In this manuscript we develop a dosimetric model to predict the dose delivered to the rim of tissue surrounding the resection cavity. The model takes into account variables such as the diameter of the cavity and the degree of antibody binding which is achieved. Whilst the calculated doses to the wall of the cavity are relatively inaccurate due to our inability to measure factors such as diffusion and heterogeneity in antibody uptake, the model illustrates the potential benefits and pitfalls that can result from targeting the two radionuclides. It is hoped that as increasing interest is shown in this type of "liquid brachytherapy" other groups will find it useful to apply the model to allow comparisons to be made between our targeting strategy and those developed by other...Continue Reading

References

Oct 25, 1975·Lancet·S J Steele, M F Goodwin
Oct 1, 1979·International Journal of Radiation Oncology, Biology, Physics·M D WalkerG E Sheline
Jan 1, 1992·International Journal of Radiation Oncology, Biology, Physics·C O ScharfenK R Lamborn
Feb 15, 1991·Cancer·S M Larson
Feb 1, 1991·The British Journal of Radiology·D R WhiteJ W Dickerson
Dec 1, 1990·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·J S StewartH E Lambert
Feb 1, 1989·International Journal of Radiation Oncology, Biology, Physics·J S StewartH E Lambert
Jan 1, 1988·European Journal of Nuclear Medicine·A C PerkinsM V Pimm
Dec 1, 1987·Journal of Clinical Oncology : Official Journal of the American Society of Clinical Oncology·A A EpenetosG B Sivolapenko
Jun 1, 1986·British Journal of Cancer·D PectasidesH Durbin
May 1, 1995·Zygote : the Biology of Gametes and Early Embryos·K AshC C Calvert
Feb 1, 1995·Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology·K HopkinsJ T Kemshead

❮ Previous
Next ❯

Citations

Oct 24, 2007·Cancer Letters·Markus Jensen, Frank Berthold
Dec 17, 2005·Physics in Medicine and Biology·George MardirossianPatrick Stevens

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cell Adhesion Molecules in the Brain

Cell adhesion molecules found on cell surface help cells bind with other cells or the extracellular matrix to maintain structure and function. Here is the latest research on their role in the brain.

Related Papers

Radiotherapy and Oncology : Journal of the European Society for Therapeutic Radiology and Oncology
K HopkinsJ T Kemshead
BioDrugs : Clinical Immunotherapeutics, Biopharmaceuticals and Gene Therapy
T WunJ M Tuscano
European Journal of Cancer & Clinical Oncology
M A BurtonN Hardy
© 2022 Meta ULC. All rights reserved