A model to investigate xerostomia-related dental caries

Caries Research
J JansmaD H Retief

Abstract

The aim of this study was to develop an in vivo model in which onset, progression, and prevention of xerostomia-related dental caries can be studied. The progress of the caries process was investigated on ground and polished human enamel blocks placed in the lower denture of 7 edentulous subjects suffering from xerostomia. During a period of 6 weeks the samples were analyzed at weekly intervals by means of scanning optical monitoring, scanning longitudinal microradiography, scanning electron microscopy, and hardness measurements. Although the indentation length increased significantly within 2 weeks, no demineralization could be yet observed with scanning optical monitoring, longitudinal microradiography, and electron microscopy in most samples. Starting from the 3rd week a progressive demineralization could be observed by all methods. The mineral loss (hydroxyapatite) in the 3rd week was 0.0126 kg.m-2 (median) which increased to 0.0761 kg.m-2 after 6 weeks. Scanning electron microscopy showed a destruction which resembled that of natural xerostomia-related dental caries. From this study it may be concluded that the in vivo model developed is suitable for studying onset, progression, and prevention of xerostomia-related dental ...Continue Reading

Citations

Dec 23, 2011·Strahlentherapie und Onkologie : Organ der Deutschen Röntgengesellschaft ... [et al]·R SchweyenT Kuhnt
Feb 4, 2010·Oral Surgery, Oral Medicine, Oral Pathology, Oral Radiology, and Endodontics·Franck JegouxG Daculsi
Aug 23, 2011·Practical Radiation Oncology·Mary P WalkerKaren B Williams
Jun 12, 2003·Critical Reviews in Oral Biology and Medicine : an Official Publication of the American Association of Oral Biologists·A VissinkR P Coppes
Feb 23, 2007·Journal of Dental Research·F X Lü, R S Jacobson
May 26, 2017·British Journal of Nursing : BJN·Katie HumphreysSam Shah
Apr 1, 1992·Journal of Dental Research·R H Manning, W M Edgar

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