A Moderate Daily Dose of Resveratrol Mitigates Muscle Deconditioning in a Martian Gravity Analog

Frontiers in Physiology
Marie MortreuxSeward B Rutkove

Abstract

While there is a relatively good understanding of the effects of microgravity on human physiology based on five decades of experience, the physiological consequences of partial gravity remain far less well understood. Until recently, no model had been able to replicate partial gravity such as that experienced on Mars (0.38 g), which would be critical to help sustain long-term missions and ensure a safe return to Earth. Recent development of two partial weight bearing (PWB) models, one in mice and one in rats, now allows for quadrupedal partial unloading that mimics Martian gravity. Resveratrol (RSV), a polyphenol most commonly found in grapes and blueberries, has been extensively investigated for its health benefits, including its anti-inflammatory, anti-oxidative, and anti-diabetic effects. In the context of mechanical unloading, RSV has also been shown to preserve bone and muscle mass. However, there is a lack of research regarding its effect on the musculoskeletal system in partial gravity. We hypothesized that a moderate daily dose of RSV (150 mg/kg/day) would help mitigate muscle deconditioning in a Mars gravity analog. Indeed, our results demonstrate that RSV treatment during partial unloading significantly preserves musc...Continue Reading

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Citations

Dec 17, 2019·Acta Physiologica·Rizwan QaisarAdel B Elmoselhi
Apr 21, 2020·Frontiers in Physiology·Carson SempleMarie Mortreux
Sep 18, 2020·Journal of Applied Physiology·Megan E Rosa-CaldwellNicholas P Greene
Apr 28, 2021·Journal of Environmental Science and Health. Part C, Toxicology and Carcinogenesis·Jeffrey S WilleyXiao Wen Mao
May 15, 2021·Frontiers in Systems Neuroscience·Timothy R MacaulayJacob J Bloomberg
Oct 7, 2021·Physiological Reports·Marie MortreuxSeward B Rutkove

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