A moderate increase in daily protein intake causing an enhanced endogenous insulin secretion does not alter circulating levels or urinary excretion of dehydroepiandrosterone sulfate

Metabolism: Clinical and Experimental
T RemerF Manz

Abstract

To study the effect of a moderate increase in insulin secretion produced by an increased daily protein intake on dehydroepiandrosterone sulfate (DHEAS), a balanced randomized crossover trial consisting of three strictly controlled dietary regimens was performed in six healthy male volunteers. The basic diet (B) contained 50 g protein/d; diets P and M (also basic diets) were enriched with either 32 g protein/d (P) or 10 mmol L-methionine/d (M). Methionine was given (as a specific nonprotein source of endogenously derived sulfate) to control for possible confounding effects on DHEAS due to an increased sulfate supply. At the end of each 4-day diet period, blood and 24-hour urine samples were collected. Fasting plasma levels of testosterone, cortisol, insulin-like growth factor-I (IGF-I), and insulin, as well as urinary output of total (hot acid-cleaved) testosterone conjugates and 3alpha-androstanediol glucuronide, did not show significant changes in response to dietary manipulations. Endogenous sulfate availability (as reflected by renal sulfate output per 24 hours) approximately doubled with diets P and M. However, plasma levels (6.3 +/- 1.5, 6.8 +/- 1.8, and 6.9 +/- 2.1 micromol/L for B, P, and M, respectively) and urinary exc...Continue Reading

Citations

May 26, 1999·The British Journal of Nutrition·T RemerF Manz
Nov 18, 2006·The Journal of Alternative and Complementary Medicine : Research on Paradigm, Practice, and Policy·Mary H McMullenMindy S Kurzer
Dec 15, 2010·International Journal of Molecular Sciences·Chunmei Gu, Huiyong Xu
Sep 15, 2020·American Journal of Lifestyle Medicine·Michael Greger
Jun 3, 2005·Current Opinion in Clinical Nutrition and Metabolic Care·Frédéric TremblayAndré Marette
Sep 24, 2004·Diabetes/metabolism Research and Reviews·Itamar RazEleazar Shafrir
Aug 2, 2007·Annual Review of Nutrition·Frédéric TremblayAndré Marette
Apr 28, 2000·Medical Hypotheses·M F McCarty

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