A modification of the uterine artery restriction technique in the guinea pig fetus produces asymmetrical ultrasound growth

Placenta
A J Turner, B J Trudinger

Abstract

To evaluate the use of diathermy ablation of branches of the uterine artery to produce growth restriction in the fetal guinea pig, and to compare this new approach with the more conventional use of uterine artery ligation. The development of growth restriction was documented by measuring fetal biparietal diameter (BPD) and the resistance index (RI) of the umbilical artery blood flow velocity waveform. At 30-35 days of gestation (term=70 days), one uterine artery was ligated in 29 sows. In another 16 sows, branches of one uterine artery were ablated using diathermy. Fetuses in contralateral horns were used as controls. Ultrasound measurements were made weekly, and at 59-69 days of gestation animals were euthanased to determine fetal position in utero as well as fetal and placental weights. In some fetuses, brain and liver weights were also recorded. Both surgical techniques resulted in similar reductions in fetal body and placental weights. The number of fetuses surviving to term was greater in the diathermy group (53%) compared to the ligation group (22%) (P<0.05). Results from these two groups were combined and referred to as "treated" fetuses. The brain/liver weight ratio was increased by 245% in the treated fetuses compared ...Continue Reading

Citations

Mar 26, 2016·Frontiers in Physiology·Amanda N Sferruzzi-Perri, Emily J Camm
Mar 2, 2013·American Journal of Reproductive Immunology : AJRI·Elizabeth A Bonney
Sep 15, 2015·The Journal of Steroid Biochemistry and Molecular Biology·Jonathan J HirstHannah K Palliser
May 21, 2016·Frontiers in Neurology·Prakasham RumajogeeMichael G Fehlings
Oct 23, 2015·Journal of Developmental Origins of Health and Disease·B J KrauseP Casanello
Jul 26, 2013·Reproductive Sciences·Hannah K PalliserJonathan J Hirst
Sep 6, 2015·Reproductive Sciences·Alexander A EliasBryan S Richardson
Jul 7, 2017·American Journal of Physiology. Regulatory, Integrative and Comparative Physiology·Sifa TuranLoren P Thompson
Jan 24, 2019·Genesis : the Journal of Genetics and Development·Natalie ShukrunAbraham Fainsod
Feb 19, 2016·Physiology·Sherin U Devaskar, Alison Chu
May 16, 2017·Journal of Developmental Origins of Health and Disease·A L CumberlandJ J Hirst

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